Akca, H.

Mammadov, R.

Tokgun, O.

English

Электронная библиотека БГУ

Биоинженерия. Трансгенные технологии
221
CONVOLVULUS GALATICUS, CROCUS ANTALYENSIS, AND LILIUM
CANDIDUM EXTRACTS SHOW THEIR ANTITUMOR ACTIVITY THROUGH
INDUCTION OF P53-MEDIATED APOPTOSIS ON HUMAN BREAST CANCER
CELL LINE MCF-7 CELL
Akca H, Tokgun O, Mammadov R.
Pamukkale University, Kınıklı, Denizli, Turkey; rmammad@yahoo.com
Conventional and newly emerging treatment procedures such as chemotherapy, catalytic
therapy, photodynamic therapy, and radiotherapy have not succeeded in reversing the out-
come of cancer diseases to any drastic extent, which has led researchers to investigate al-
ternative treatment options. The extensive repertoire of traditional medicinal knowledge
systems from various parts of the world are being re-investigated for their healing proper-
ties. It has been reported that several members of the Convolvulaceae, Iridaceae, and Lili-
aceae families have antitumor activity against some tumor cell lines. Here we first report
that Convolvulus galaticus, Crocus antalyensis, and Lilium candidum species have cyto-
toxic activity on human breast cancer cell line MCF-7 cells. Plant samples were collected
and identified, and their cytotoxic effects on the MCF-7 cell line were examined at differ-
ent concentrations of methanol extracts. We found that all three plants have cytotoxic ef-
fects on MCF-7 cells but that C. galaticus has the strongest cytotoxic effect even in the
lowest extract concentration tested (0.32 μg/mL). Our results indicate that these plant ex-
tracts have cytotoxic effects on human breast carcinoma cell line MCF-7 cells and that this
cytotoxic effect comes from p53-mediated stimulation of apoptosis.


Convolvulus galaticus, Crocus antalyensis, and Lilium candidum extracts show their antitumor activity through induction of P53-mediated apoptosis on human breast cancer cell line MCF-7 cell

http://elib.bsu.by/bitstream/123456789/34909/1/185.pdf

Convolvulus galaticus, Crocus antalyensis, and Lilium candidum extracts show their antitumor activity through induction of P53-mediated apoptosis on human breast cancer cell line MCF-7 cell

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