Arslan, Idris

Celik, Ali

English

Электронная библиотека БГУ

Фотосинтез, биохимические процессы, регуляция клеточного метаболизма
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GYPSOPHILA GENUS: A RICH SOURCE OF SAPONIN TRIGGERS
TOXICITY ENHANCING PROPERTIES ON SAPORIN A TYPE-I RIP
Idris Arslan, Ali Celik
Pamukkale University, Biology Department, Denizli, Turkey; iarslan@pau.edu.tr
Saponins are a widespread class of natural compounds found in a lot of plant species.
Saponins consist of a hydrophobic triterpenoidal C30 or steroidal C27 backbone and one or
two hydrophilic glycoside moieties attached to the backbone. Due to this structural compo-
sition, saponins are amphiphilic glycoconjugates which give soap-like foams in water.
Analysis of saponin compounds, however, can be quite compelling due to such factors as
their complexity, amphiphilic structure, lack of strong chromophore and prone to form un-
soluable aggregates in solution which can make purification and quantitation difficult. Un-
der-ground parts from Gypsophila species are an especially rich source of triterpene sapon-
ins. They are exploited commercially for a variety of purposes including medicines, deter-
gents, adjuvants and cosmetics. The most common basic structures of sapogenins isolated
from Gypsophila genus are mainly gypsogenin but also in fewer amounts gypsogenic acid
and quillaic acid. Also, saponins with an aldehyde function at C-4 from Gypsophila pilulif-
era exhibited cytotoxic activity against human cancer cell line. The function of saponins in
plants is not completely elucidated but there is strong evidence that they act as defense
compounds against fungal pathogens’ attack. In addition, many plant saponins have been
isolated and present a broad spectrum of biological uses, such as anti-cancer, anti-
inflammatory, ion channel blocking, immune stimulating, antifungal, antithrombotic and
hypocholesterolemic property. Gypsophila saponins are of interest in terms of their appli-
cations in vaccines.
Key Words: Gypsophila, triterpene saponin, cytotoxicity, saporin.


Gypsophila genus: a rich source of saponin triggers toxicity enhancing properties on saporin a type-I RIP

http://elib.bsu.by/bitstream/123456789/33458/1/004.pdf

Gypsophila genus: a rich source of saponin triggers toxicity enhancing properties on saporin a type-I RIP

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