Bergin FG

Gicquel J

Hanson JM

Lamb CA

Mansfield JC

Mohiuddin MK

Neely D

Background: Identifying Crohn\u27s disease recurrence in symptomatic patients after ileocaecal resection is difficult. The aim of this study was to evaluate faecal concentrations of granulocyte degradation products in this setting. Methods: A postoperative cohort of 13 patients was followed prospectively for 1 year with regular faecal calprotectin (FC) and lactoferrin (FL) measurements. A second postoperative cohort (median 24 months after resection) of 104 patients provided a single stool sample. Faecal measurements were compared with symptom diaries, the Harvey Bradshaw Index, endoscopic examination, C-reactive protein and platelet measurement. Results: In the uncomplicated course, both markers normalized within 2 months. Both FC and FL correlated significantly with Harvey Bradshaw Index (

Faecal calprotectin or lactoferrin can identify postoperative recurrence in Crohn\u27s disease

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