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GSTP1 c.313A>G polymorphism in Russian and Polish athletes
Authors
Ahmetov I.
Cieszczyk P.
+9 more
Jastrzebski Z.
Leonska-Duniec A.
Leznicka K.
Maciejewska-Skrendo A.
Sawczuk M.
Semenova E.
Trybek G.
Zarebska A.
Zmijewski P.
Publication date
1 March 2020
Publisher
Abstract
© 2017 the American Physiological Society.The GSTP1 gene encodes glutathione S-transferase P1, which is a member of the glutathione S-transferases (GSTs), a family of enzymes playing an important role in detoxification and in the antioxidant defense system. There is some evidence indicating that GSTP1 c.313A>G polymorphism may be beneficial for exercise performance. Therefore, we decided to verify the association between the frequency of GSTP1 c.313A>G variants, physical performance, and athletes’ status in two cohorts: in a group of Russian athletes (n = 507) and in an independent population of Polish athletes (n = 510) in a replication study. The initial association study conducted with the Russian athletes revealed that the frequency of the minor G allele was significantly higher in all athletes than in controls; that was confirmed in the replication study of Polish athletes. In the combined cohort, the differences between athletes (n = 1017) and controls (n = 1246) were even more pronounced (32.7 vs 25.0%, P G single nucleotide polymorphism is associated with improved endurance performance. These observations could support the hypothesis that the GSTP1 G allele may improve exercise performance by better elimination of exercise-induced ROS
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Last time updated on 04/04/2020