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Binase induces apoptosis of transformed myeloid cells and does not induce T-cell immune response
Authors
Ilinskaya O.
Makarov A.
+4 more
Mitkevich V.
Petrushanko I.
Prassolov V.
Zelenikhin P.
Publication date
29 February 2020
Publisher
Abstract
Microbial RNases along with such animal RNases as onconase and BS-RNase are a promising basis for developing new antitumor drugs. We have shown that the Bacillus intermedius RNase (binase) induces selective apoptosis of transformed myeloid cells. It attacks artificially expressing activated c-Kit myeloid progenitor FDC cells and chronic myelogenous leukemia cells K562. Binase did not induce apoptosis in leukocytes of healthy donors and in normal myeloid progenitor cells. The inability of binase to initiate expression of activation markers CD69 and IFN-γ in CD4+ and CD8+ T-lymphocytes testifies that enzyme is devoid of superantigenic properties. Altogether, these results demonstrate that binase possesses therapeutic opportunities for treatment of genotyped human neoplasms expressing activated kit. © 2007 Elsevier Inc. All rights reserved
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oai:rour.neicon.ru:rour/139558
Last time updated on 04/04/2020
National Open Repository Aggregator (NORA)
See this paper in CORE
Go to the repository landing page
Download from data provider
oai:rour.neicon.ru:rour/175042
Last time updated on 04/04/2020