The study identified strengths and weaknesses in research governance at the University of Ghana (UG) with respect to the organization of research, Institutional Steering of Research and the management of research. It presents issues, capacity building requirements, and recommendations to the government of Ghana, the University of Ghana, research funders and researchers. It recommends the government of Ghana put in place a National Research Policy and provide improved infrastructure to promote research governance at UG. Capacity building requirements include training in research project management and administration, fund raising and proposal writing, dissemination of results, and strategic planning