Complexation of thiacalix[4]arene methylphosphonic and sulphonic acids with amino acids

Abstract

In this paper, host-guest complexation process of thiacalix[4]arene tetrakis-methylphosphonic and tetrakis-sulphonic acids with amino acids by HPLC and molecular modelling methods has been studied. It was shown that thiacalix[4]arene tetrakis-methylphosphonic acid due to transformability of macrocyclic skeleton and flexibility of methylphosphonic substituents can adopt its conformation for strong multicentre binding of the amino acids with association constant values 530-10,140 M-1 in water. © 2013 Taylor & Francis Group, LLC