Blacker J

Clutterbuck LA

Crampton MR

Grosjean C

North M

VanadiumV(salen) complex 3 has been found to be an effective catalyst for the asymmetric addition of hydrogen cyanide (generated in situ from trimethylsilyl cyanide) to imines. The best results (up to 81% enantiomeric excess) were obtained for aromatic imines in which the nitrogen atom is protected with a benzyl group and in which the imine bond is not sterically encumbered. \ua9 2006 Elsevier Ltd. All rights reserved

Catalytic, asymmetric Strecker reactions catalysed by titanium<sup>IV</sup> and vanadium<sup>V</sup>(salen) complexes

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