Aarsland D

Ballard CG

Ehrt U

Francis PT

Larsen JP

Perry EK

Perry RH

Piggott MA

Sharp SI

Ziabreva I

Background: Serotonin 1A receptors (5-HT1A) have not been studied in dementia with Lewy bodies (DLB) or Parkinson\u27s disease dementia (PDD) patients with depression. Aim: To examine 5-HT1A in DLB and PDD postmortem in relation to depression. Methods: [H-3]8-hydroxy-2-dipropylaminotetralin binding to 5-HT1A was determined in temporal cortex (Brodmann areas, BA20 and BA36) from 10 DLB patients, 17 PDD patients and 9 controls. Results: 5-HT1A density was significantly higher in BA36 in combined DLB/PDD patients with depression, but was unaltered in BA20. Conclusion: Higher BA36 5-HT1A density in PDD and DLB patients than in control is dependent on whether the patient had experienced depression during life, not DLB/PDD diagnosis. A 5-HT1A antagonist adjuvant may improve treatment of depression in dementia. Copyright (C) 2008 S. Karger AG, Base

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Cortical Serotonin 1A Receptor Levels Are Associated with Depression in Patients with Dementia with Lewy Bodies and Parkinson\u27s Disease Dementia

Cortical Serotonin 1A Receptor Levels Are Associated with Depression in Patients with Dementia with Lewy Bodies and Parkinson\u27s Disease Dementia

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