Application of NMR spectroscopy in predicting hydrogel matrix stability by “stress” testing method

Abstract

The results of the study of hydrogel matrix stability by means of nuclear magnetic resonance spectroscopy are described in the article. Ionizing radiation effect on auxiliary substances and active ingredients of hydrogel polymeric matrixes have been studied. It has been proved that under the influence of high-velocity electrons at absorbed doses 25–35 kGy the formation of a three-dimensional polymeric structure of the matrix occurs. It has been ascertained that active ingredients of hydrogels miramistin and gentamycin are stable under absorbed radiation doses in the range 5–35 kGy