The modern setting of indications to surgical treatment of appendicitis is still complex problem in spite of reached success and wide usage of modern diagnostic methods. The researches of erythrocytes of venous blood of children with superficial (catarrhal) (10) and phlegmonic(destructive) (35) appendicitis were performed. The cells were explored with help of atomic power microscopy. The removed appendixes were explored with help of light microscopy, scanning probe microscopy as well as atomic power microscop