Is Spatial Distribution of the HIV-1-resistant CCR5Delta32 Allele Formed by Ecological Factors?

Abstract

yesBSUIt has been proposed that the D 32 mutation in the chemokine receptor gene, inducing resistance to HIV-1 and, probably, to other virus infections, has undergone selection in historical times. The frequency of this mutant allele has changed rapidly both in time (during the last two millennia) and in space (across Eurasia