It was determined that acute rhinosinusitis is a sufficiently widespread disease in the otorhinolaryngology of Ukraine, especially in Kyiv, Kharkiv and Rivne regions, and with the lowest prevalence in the Zaporizhzhya and Kirovograd regions for the research period of 2012- 2017. It has also been found that acute rhinosinusitis affects men as and women with an average age of 37.0 ± 5.5 and 42.0 ± 24 respectively. Modern approaches to the pharmacotherapy of acute rhinosinusitis are carried out in accordance with the protocol for the provision of medical care to patients and are comprehensive and directed at the main components of the etiopathogenesis of the disease. But it is necessary to update the approaches to treatment of acute rhinosinusitis constantly, taking into account the latest researches on pharmacotherapeutic support of patient