Аналіз чинників, що асоційовані з контролем офісного і домашнього артеріального тиску в пацієнтів, котрі отримують алгоритмізовану антигіпертензивну терапію
Aim. To define factors, associated with attaining control of the office and home AP and with the number of necessary medicaments in patients with non-complicated AH after 6 month of algorithmic antihypertensive therapyMaterials and methods. 501 patients with AH received therapy according to the algorithm that provided successive prescription of fixed combination of perindopril, ampodipine and if necessary, indapamide-retard, spironolactone, moxonidine or doxazosin for attaining the target office AP. The office and home AP was assessed by certificated oscillometric devices. For determination of factors, independently associated with attaining the target level of office and recommended level of home AP after 6 months of therapy the multiple linear regressive analysis was usedResults. After 6 months the office SAP and DAP decreased from 165,7±13,9 to 131,0±9,5 and from 96,9±9,7 to 79,3±7,1mm of m.c., home – from 148,8±15,7 to 129,4±8,3 and from 87,8±10,0 to 77,9±7,2 mm of m.c. After 6 months the target office AP was attained by 80,1 %, recommended home – by 65,8 % of patients. After 7 days indapamide-retard was added to the therapy in 24 % of patients. At the end of research 165 (37,2 %) patients were treated by three or more preparations. The high inclination to treatment was detected in 49, moderate – in 43,6, low – in 7,4 % of patientsConclusions. The attainment of target office AP in patients with hypertension in 6 month of treatment was independently associated with female sex, age, initial level of office SAP, absence of the need in 3 preparations after 7 days of treatment, high compliance. The need of prescription of three and more preparations for AP control after 6 month was associated with low compliance, probable resistant AH before inclusion in the research, home SAP after 7 days and uncontrolled AH after 1 month of treatmentЗ досягненням цільового офісного АТ в пацієнтів з АГ через 6 місяців лікування асоціювались жіноча стать, рівень вихідного офісного САТ, відсутність потреби у 3-х препаратах через 7 днів лікування, високий комплаенс. З досягненням рекомендованого домашнього АТ через 6 місяців лікування асоціювались вік, жіноча стать, рівень вихідного офісного САТ, високий комплаен
