Introduction: Periapical lesions often result following dental caries, pulpal infection or trauma. Their management may include both sugicl and non-surgical endodontic management. Case report: The aim of this case report was to report the successful non-surgical management of a large periapical lesion in relation to maxillary right central and lateral incisors using calcium hydroxide based sealer Sealapex for obturation. The case was periodically reviewed and showed signs of almost complete periapical healing after six months. Discussion: Traditionally, calcium hydroxide is the material of choice for inducing periapical healing when used as an intracanal medicament or as a root canal sealer. In this case, the non-surgical healing of the large periapical lesions using a calcium hydroxide based sealer provided favorable clinical and radiographic response. Conclusion: The calcium hydroxide based sealer when used for obturation in non-surgical management of a large perapical lesion showed a successful treatment outcome
