Ozonolysis is widely used in organic synthesis to obtain aldehydes and ketones from
alkenes, a process of great interest, for example, for the pharmaceutical industry. This
reaction is more environmentally accepted than other alternative oxidations and it has
good atom efficiency. Ozonolysis, however, has an important drawback; the ozonides
generated as intermediates in the process are unstable and pose a risk of explosion. To
minimize this risk, continuous flow processing can be used, as this eliminates the
accumulation of large amounts of hazardous intermediates, thereby offering an
alternative to batch processing that greatly enhances the control and safety of the
ozonolysis process.1,2 Here we report on the results obtained with an air plasma-driven
continuous-flow ozonolysis system. (... continues
