This thesis describes the development of new pathways towards the synthesis of novel
antimicrobial (and anticancer) agents. Two synthetic protocols based on free radical chemistry
are studied, which are used to access polycyclic heterocyclic compounds of potential biological
importance. Both these procedures involve the generation of radicals using Bu3SnH and AIBN
initiators, and the subsequent intramolecular radical cyclisation onto the imidazole ring. Radical
cyclisations onto benzimidazoles and pyrroles are also described. [Continues.
