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Orbitofrontal cortex is selectively activated in a primate model of attentional bias to cocaine cues
Authors
A Elton
AC Janes
+46 more
BA Anderson
BA Anderson
BE Wexler
C Hickey
C Padoa-Schioppa
CH Luk
Charles W. Bradberry
CW Bradberry
DG Smith
E Awh
EH Baeg
ET Rolls
Eunha Baeg
G Paxinos
G Schoenbaum
H Garavan
Hank P. Jedema
HF Kim
JD Elsworth
JW Kable
KD Ersche
L Chelazzi
L Tremblay
LC Maas
LE Grattan
LJ Porrino
M Field
MA Parvaz
MR Roesch
NK Logothetis
O Bartra
PH Rudebeck
RZ Goldstein
RZ Goldstein
RZ Goldstein
S Grant
S Miocinovic
S Yamamoto
SBM Yoo
SG Kim
SN Haber
ST Carmichael
SW Kennerley
TR Kosten
VB McGinty
W Schultz
Publication date
1 March 2020
Publisher
'Springer Science and Business Media LLC'
Doi
Cite
Abstract
© 2019, The Author(s).Attentional bias to drug-associated cues correlates with extent of current use, and risk of relapse among those attempting abstinence. Electroencephalogram (EEG) and functional imaging measures in clinical studies have previously investigated the neural basis of attentional bias, but the lack of animal models precluded investigation at the single-unit level. To complement results obtained from clinical studies, we have employed a non-human primate model of attentional bias to cocaine cues while simultaneously recording single-unit activity in cortical and striatal regions implicated in reward processing. Rhesus macaques conditioned to associate particular colors with cocaine or water reward performed an attentional bias task, in which those colors served as irrelevant distractors. Concurrently, multiple electrode arrays for recording single-unit activity were acutely implanted into the orbitofrontal cortex, anterior cingulate cortex, dorsal anterior striatum, and ventral striatum. As in clinical studies, attentional bias was indicated by elongated response times on trials with cocaine-associated distractors compared with trials with water-associated, or control unconditioned distractors. In both animals studied, across an unbiased sample of neurons, the orbitofrontal cortex differentiated distractor condition by the proportion of single-units activated, as well as by population response. In one of the two, the anterior cingulate cortex did as well, but neither striatal region did in either animal. These direct measures of single-unit activity in a primate model complement clinical imaging observations suggesting that cortical mechanisms, especially in orbitofrontal cortex, are likely involved in attentional bias to cocaine-associated environmental cues11sciescopu
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oai:pr.ibs.re.kr:8788114/6990
Last time updated on 25/03/2020
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Last time updated on 05/09/2020