A Prospective Open Labelled Phase-II Non- Randomized Clinical Trial on “NERUNJI VER KUDINEER” for “KALLADAIPPU” (UROLITHIASIS)

Abstract

KALLADAIPPU is the most common disease in our country. The evidence of the disease KALLADAIPPU was derived from YUGI VAIDHIYA CHINTHAMANI 800, by Dr.K.Anbarasu B.S.M.S (Page.No.283). The clinical features of KALLADAIPPU can be correlated with UROLITHIASIS in modern science. Urolithiasis is a term originated from three Greek words “ouron” for urine, “oros” for flow, and “lithos” for stone. It is the formation of calculi which are formed or located anywhere in the urinary system (i.e. kidneys, bladder, urethrae, and urinary tract). Many herbal and herbal-mineral formulations have been described in Siddha text books. One such drug NERUNJI VER KUDINEER mentioned in the book of AATHMARATCHAMIRTHAM ENNUM VAIDHYA SARASANGIRAGAM (Page.no:349). A total of 40 patients of both sex (20 OPD and 20 IPD) were selected and administered with the clinical trial medicine “NERUNJI VER KUDINEER” 100 ml BID at PG Department of Pothu Maruthuvam, Govt. Siddha Medical College and Hospital, Palayamkottai. The whole study period is between August 2018 and June 2019. The clinical trial medicine was subjected to Biochemical, Toxicity and Pharmacological studies. In clinical study 75% of out patients and 50% of in patients showed Good response. And 25% of Out patients and 45% In patients showed Moderate response. Poor response in 5% of IPD. No Adverse reaction was found in this clinical study. The statistical analysis showed good significant value (P<0.0001). The Nerunji ver Kudineer is safe and effective and affordable cost in the treatment of Kalladaippu Noi (Urolithiasis)

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