This study aims to evaluate the quality of Life in children (ages between 3-16 years) receiving permanent renal dialysis in Gaza strip. The design of this study is case-control. All cases in Gaza strip were included in the study (15cases) and compared with the control group (45 individuals without the disease) that were selected accordance to the cases sex, age, living places, monthly income and the relationship between parents. The study sample was interviewed by the researchers and completed the developed questionnaire, which focused on quality of life and included five domains, these domains are Physical health, Psychological health, Social relationships, Environment health and Personal safety. Validity and reliability of the instrument were tested and the total instrument reliability test (Cronbach's Alpha) was 0.74, while by Split half methods was 0.94. The study revealed statistically significant difference (< 0.001) between cases and control in all study domains except the environmental health domain. The educational achievement deteriorated significantly as a result of impairment of physical health, psychological health and social relationships. Also, the study revealed that the altered levels of serum electrolytes secondary to renal failure and dialysis are responsible for signs and symptoms that the patients experience. The study domains did not show statistically significant difference when compared by sex, age, living places, monthly income and the relationship between parents. The study also revealed that there was a bad need to pay more attention when caring and dealing with dialyzed patients. Special food supplementation should
