Selection of hotel is of high priority and significance for tourists and entails a complicated decision-making process. The paper aims at identifying the most significant hotel selection factors taken into account by Greek customers. An empirical research study was conducted using an online survey. Ten factors identified by literature review included in the investigation. The findings indicate that Cleanliness is the most important factor in the selection of accommodation, followed by Price and Staff. Considering the priorities of tourists, hotel managers may design more effectively their segmentation, targeting and positioning strategy to ensure that their offerings match the needs and wants of their guests