A comparative study was conducted to evaluate the influence of two different severe plastic deformation (SPD) processes: repetitive corrugation and straightening (RCS) and high-pressure torsion (HPT). Samples of an Al-3Mg-0.25Sc alloy with an initial grain size of ∼150 μm were processed by RCS through 8 passes at room temperature either without any rotation during processing or with a rotation of 90° around the longitudinal axis between each pass. Thin discs of the alloy were also processed for up to 5 turns by HPT at room temperature. The results show that both procedures introduce significant grain refinement with average grain sizes of ∼0.6–0.7 μm after RCS and ∼95 nm after HPT. Measurements of the Vickers microhardness gave values of ∼128 after RCS and ∼156 after HPT. The results demonstrate that processing by HPT is the optimum processing technique in achieving both high strength and microstructural homogeneity