Xanthine Oxidase (XO) inhibitors may contribute to the increased incidence of several inflammatory diseases such as gout. Inhibition of XO enzyme activity plays a significant role in the prevention and treatment of these types of diseases. The aim of present study were to synthesize, determine the cytotoxicity and biological activity, and molecular docking of a few Dihydropyridines as XO Inhibitors. The synthesis of a few 1, 4-dihydropyridine (DHP) derivatives (A-C) were evaluated for their cytotoxicity effects against MCF-7 and L929 cells. All the selected compounds / All the potential candidate compounds were also evaluated for their XO inhibitory activity. Molecular docking simulation was used to investigate the potential binding modes of DHP derivatives within XO binding site. The results of this study showed the superior cytotoxic activities of compound B against both tested cell lines, while no significant XO inhibitory activity was recorded for it. On the basis of molecular docking studies, different enzyme blocking activities might be attributed to the various binding sites with the enzyme active sites
