Armand M. Leroi

David C. Wedge

DC Johnson

EG Leigh Jr.

Florian Markowetz

HA Herzog

I Bozic

I Martincorena

I Varela

Iñigo Martincorena

Jones

LR Yates

M Greaves

M Nei

Maxime Tarabichi

MJ Williams

Moritz Gerstung

N Andor

N Goldman

O Al Hammal

Ole Christian Lingjærde

Paul T. Spellman

PC Nowell

Peter Van Loo

Quaid D. Morris

S Nik-Zainal

SA Forbes

SC Dentro

TI Zack

Van Loo

Nature Genetics

English

Tarabichi, Maxime

Martincorena, Iñigo

Gerstung, Moritz

Leroi, Armand M.

Markowetz, Florian

Spellman, Paul T.

Morris, Quaid D.

Lingjærde, Ole Christian

Wedge, David C.

Loo, Peter Van

The University of Manchester - Institutional Repository

Neutral tumor evolution?

The PCAWG Evolution and Heterogeneity Working Group,

Van Loo, Peter

Yuan, Ke

Enlighten: Publications

To the Editor — Tumor growth is an evolutionary process that is governed by somatic mutation, clonal selection and random genetic drift, and is constrained by the coevolution of the microenvironment1,2. Tumor subclones are subpopulations of tumor cells with a common set of mutations resulting from the expansion of a single cell during tumor development, and they have been observed in a substantial fraction of cancers and across multiple cancer types3. Peter Nowell has proposed that tumors evolve through sequential genetic events4, whereby one cell acquires a selective advantage so that its lineage becomes predominant. According to this traditional model, the selective advantage is conferred by a small set of driver mutations, but as the subclones that bear them successively expand, they also accumulate passenger mutations, which can be detected in sequencing experiments1. Genomes of individual tumors contain hundreds to many thousands of these genetic variants at a wide range of frequencies5,6. Because genetic drift can drive novel variants to high frequencies, it is of great interest to discern the relative importance of selection and drift in shaping the frequency distribution of variants in any given tumor

Leroi, Armand M

PCAWG Evolution and Heterogeneity Working Group

Spellman, Paul T

Morris, Quaid D

Wedge, David C

Princeton University Open Access Repository

Martincorena, Inigo

DI-fusion

Schlesner, Matthias

OPUS Augsburg

Neutral tumor evolution? [Letter]

Crossref

The PCAWG Evolution and Heterogeneity Working Group

Enlighten

https://opus.bibliothek.uni-augsburg.de/opus4/files/92410/92410.pdf

Neutral tumor evolution?

Abstract

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