This work depicts the Supply Chain of Innovation (SCoI) including only those kinds of relationships related to the purchase and selling of R&D commodities. The theoretical framework represents the propensity of a firm in improving its innovation performance thanks to its collaboration experience and positioning in SCoI. We validate our theoretical framework on a sample of 208 biotechnology companies involved in 814 SCoI agreements. Our results show the positive direct impact of SCoI collaboration experience on innovation performance and a mediating role of positioning in SCoI on the abovementioned link