Gaipl, US

Multhoff, G

Pockley, AG

Rödel, F

Frontiers in Oncology

English

PubMed

Gabriele Multhoff

Franz Rödel

Alan G. Pockley

Udo S. Gaipl

Frontiers - Publisher Connector

www.frontiersin.org March 2013 | Volume 3 | Article 55 | 1
Editorial
published: 25 March 2013
doi: 10.3389/fonc.2013.00055
Frontiers research topic: radiation-induced effects and the 
immune system
Gabriele Multhoff 1*, Franz Rödel 2, Alan G. Pockley 3 and Udo S. Gaipl 4
1 Radiation Oncology, Klinikum Rechts der Isar, Technische Universität München, Munich, Germany
2 Radiation Therapy and Oncology, University Hospital Frankfurt, Frankfurt, Germany
3 John van Geest Cancer Research Centre, Nottingham, UK
4 Radiation Oncology, University Hospital Erlangen, Erlangen, Germany
*Correspondence: gabriele.multhoff@lrz.tu-muenchen.de
Edited by:
Lorenzo Galluzzi, Institut National de la Santé et de la Recherche Medicale, France
Reviewed by:
Lorenzo Galluzzi, Institut National de la Santé et de la Recherche Medicale, France
 delivery of macromolecules and other therapeutics to irradiated 
tumors. A major focus of this e-book is to elucidate immunologi-
cal facets of ionizing irradiation. It is indeed becoming clear that 
high- and  low-dose irradiation elicit distinct immunological effects. 
Furthermore, the mode of irradiation-induced cell death (e.g., apop-
tosis, necrosis) has a major impact on anticancer immune responses. 
Overall, the e-book aims at review the current knowledge on the 
role of ionizing irradiation in antitumor immunity. This knowl-
edge is instrumental for the development of innovative therapeutic 
modalities involving the combination of radio(chemo)therapy and 
immunotherapy in patients with locally advanced tumors.
Received: 26 February 2013; accepted: 01 March 2013; published online: 25 March 2013.
Citation: Multhoff G, Rödel F, Pockley AG and Gaipl US (2013) Frontiers research topic: 
radiation-induced effects and the immune system. Front. Oncol. 3:55. doi: 10.3389/
fonc.2013.00055
This article was submitted to Frontiers in Molecular and Cellular Oncology, a specialty 
of Frontiers in Oncology.
Copyright © 2013 Multhoff, Rödel, Pockley and Gaipl. This is an open-access article dis-
tributed under the terms of the Creative Commons Attribution License, which permits use, 
distribution and reproduction in other forums, provided the original authors and source 
are credited and subject to any copyright notices concerning any third-party graphics etc.
The development of novel, more precise instruments for the 
 delivery of ionizing radiations, the accretive utilization of protons 
and heavy ions, and the emphasis on hypofractionated irradia-
tion schemes have resulted in major improvements in locoregional 
tumor control. However, radiation therapy alone is still insuffi-
cient to cure locally advanced metastatic tumors. The heteroge-
neity of neoplasms and their microenvironment also affect the 
radiosensitivity of cancers. Thus, there is an urgent clinical need 
for innovative therapeutic concepts that may be translated into 
novel radio(chemo)therapeutic regimens. In order to develop new 
therapeutic strategies, a profound knowledge of tumors and their 
microenvironment is essential.
In this e-book, the authors deal with various aspects of inter-
relationship between neoplasms and their microenvironments, 
including how high and low dose irradiation affects the immune 
system, the effects of targeted and non-targeted photon, and parti-
cle irradiation on tumor and normal tissues, as well as the impact 
of epigenetics on irradiation therapy. Furthermore, the authors 
report on the effects of irradiation on inflammatory pathways and 
on the microcirculation, two aspects that are highly relevant for the 


Frontiers Research Topic: Radiation-Induced Effects and the Immune System

Multhoff, Gabriele

Rödel, Franz

Pockley, Alan G.

Gaipl, Udo S.

OPUS FAU - Online-Publikationssystem der Friedrich-Alexander-Universität Erlangen-Nürnberg

Nottingham Trent Institutional Repository (IRep)

www.frontiersin.org March 2013 | Volume 3 | Article 55 | 1Editorialpublished: 25 March 2013doi: 10.3389/fonc.2013.00055Frontiers research topic: radiation-induced effects and the immune systemGabriele Multhoff 1*, Franz Rödel 2, Alan G. Pockley 3 and Udo S. Gaipl 41 Radiation Oncology, Klinikum Rechts der Isar, Technische Universität München, Munich, Germany2 Radiation Therapy and Oncology, University Hospital Frankfurt, Frankfurt, Germany3 John van Geest Cancer Research Centre, Nottingham, UK4 Radiation Oncology, University Hospital Erlangen, Erlangen, Germany*Correspondence: gabriele.multhoff@lrz.tu-muenchen.deEdited by:Lorenzo Galluzzi, Institut National de la Santé et de la Recherche Medicale, FranceReviewed by:Lorenzo Galluzzi, Institut National de la Santé et de la Recherche Medicale, France delivery of macromolecules and other therapeutics to irradiated tumors. A major focus of this e-book is to elucidate immunologi-cal facets of ionizing irradiation. It is indeed becoming clear that high- and  low-dose irradiation elicit distinct immunological effects. Furthermore, the mode of irradiation-induced cell death (e.g., apop-tosis, necrosis) has a major impact on anticancer immune responses. Overall, the e-book aims at review the current knowledge on the role of ionizing irradiation in antitumor immunity. This knowl-edge is instrumental for the development of innovative therapeutic modalities involving the combination of radio(chemo)therapy and immunotherapy in patients with locally advanced tumors.Received: 26 February 2013; accepted: 01 March 2013; published online: 25 March 2013.Citation: Multhoff G, Rödel F, Pockley AG and Gaipl US (2013) Frontiers research topic: radiation-induced effects and the immune system. Front. Oncol. 3:55. doi: 10.3389/fonc.2013.00055This article was submitted to Frontiers in Molecular and Cellular Oncology, a specialty of Frontiers in Oncology.Copyright © 2013 Multhoff, Rödel, Pockley and Gaipl. This is an open-access article dis-tributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc.The development of novel, more precise instruments for the  delivery of ionizing radiations, the accretive utilization of protons and heavy ions, and the emphasis on hypofractionated irradia-tion schemes have resulted in major improvements in locoregional tumor control. However, radiation therapy alone is still insuffi-cient to cure locally advanced metastatic tumors. The heteroge-neity of neoplasms and their microenvironment also affect the radiosensitivity of cancers. Thus, there is an urgent clinical need for innovative therapeutic concepts that may be translated into novel radio(chemo)therapeutic regimens. In order to develop new therapeutic strategies, a profound knowledge of tumors and their microenvironment is essential.In this e-book, the authors deal with various aspects of inter-relationship between neoplasms and their microenvironments, including how high and low dose irradiation affects the immune system, the effects of targeted and non-targeted photon, and parti-cle irradiation on tumor and normal tissues, as well as the impact of epigenetics on irradiation therapy. Furthermore, the authors report on the effects of irradiation on inflammatory pathways and on the microcirculation, two aspects that are highly relevant for the 

Frontiers research topic: radiation-induced effects and the immune system

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Frontiers research topic: radiation-induced effects and the immune system

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