Sustainable building development focuses on achieving buildings that meet performance and functionality requirements with minimum adverse impact on the environment. Such eco-efficiency strategies are however not feasible for achieving long-term economic and environmental objectives as they only result in damage reduction without addressing design flaws of contemporary industry. The cradle-to-cradle (C2C) design philosophy which has been described as a paradigm changing innovative platform for achieving ecologically intelligent and environmentally restorative buildings appears to offer an alternative vision which, if embraced, could lead to eco-effectiveness and the achievement of long-term environmental objectives. Adoption of C2C principles in the built environment has however been hindered by several factors especially in a sector where change has always been a very slow process. From a review of extant literature, it is argued that the promotion of current sustainable and/or gree n building strategies - which in themselves are not coherent enough due to their pluralistic meanings and sometimes differing solutions - are a major barrier to the promotion of C2C principles in the built environment. To overcome this barrier to C2C implementation, it is recommended that research should focus on developing clearly defined and measurable C2C targets that can be incorporated into project briefs from the inception of development projects. These targets could enable control, monitoring and comparison of C2C design outcomes with eco-efficient measures as well as serve as a guide for project stakeholders to achieve eco-effective “nutrient” management from the project conceptualization phase to the end of life of the building