Based on a traditional belief, Echlum amoenum (Boraginaceae) dried flowers are used In Iran as an anxiolytic remedy and also as a mood enhancer. But Interfering mechanisms unknown, In this study, efficacy of an aqueous extract of E.amoenum in depressive rat was evaluated, using measurement the changes level CSF serotonin and dopamine as indicator mood. Four groups of male wistar rats each group of seven rats were enrolled in this study. Depressive induced with intraperitoneal injection of reserpine (5mg/kg) and assessment depression by swimming test, the next two weeks of oral performing aqueous extract Echlum amoenum, CSF serotonin and dopamine concentration of rats were measured using ELISA kit. Our finding indicated, performing aqueous extract Echlum amoenum increased CSF serotonin and dopamine concentration in depression rats. The level of CSF serotonin enhanced in control group receiving Echlum amoenum compared control group alone. These results showed the serious changes of neurotransmitters due to Echlum amoenum which can be translated as mood enhancer. It can be concluded, Echlum amoenum induce antidepressant effective In part by increasing level CSF serotonin and dopamine
