This descriptive cross-sectional study was designedand carried out among 260 hospitalpersonnel working in educational and medicalcenters of Shahid Mustafa Khomeini hospital, Tehran,Iran in 2013. The demographic data of the subjects andquestions related to the history of vaccination were alsocollected. Hepatitis B surface antibody (Anti-HBS) titrationwas carried out by ELISA. Finally, the relationships betweendifferent variables and hepatitis B antibody levelswere evaluated. The results of the present study showedthat 83.8% of the hospital personnel in Tehran, as thecapital of Iran, showed a good response to hepatitis B vaccination,which was almost similar to the results of otherstudies conducted in the country. There was a significantrelationship between the and smoking, the history ofneedlestick exposures and lower years of work experience,while anti-HBs titer of the hospital personnel wasnot statistically associated with BMI, age, gender, educationlevel, occupation, interval since last vaccination, andinjection method. Enhancing the level of protection in Cardiovascularhealth staff against hepatitis B virus can leadto a decrease in the incidence of infection cases amongthe hospital personnel. Therefore, it is essential to performthe primary vaccination followed by an assessment of theresponsiveness to it. Therefore, the aim of this study wasto investigate the effect of the demographic factors onthe response rate to hepatitis B vaccination among hospitalpersonnel in Tehran. The lower response rate to hepatitisB vaccination obtained in the present study comparedto the global average necessitates further investigation onthe hospital personnel dealing with the patients directlyor indirectly in Tehran, therefore, it is essential to designlarge-scale plans to identify and treat at-risk individuals
