Bao, Y

Huo, Y. P

Leung, J.

Scheurer, R. W.

English

University of Queensland eSpace

Yan Phoebe Huo1, Yanping Bao2, Roman W. Scheurer1, Janni Leung134
1. Epidemiology and Clinical Trails, Queensland Centre for Mental Health Research, Australia; 2. National Institute on Drug Dependence, Peking University, China; 3. National 
Drug and Alcohol Research Centre, The University of New South Wales, Australia; 4. Faculty of Health and Behavioural Sciences, The University of Queensland, Australia
Childhood-onset Mental Disorders in 6 geographical regions in China:
A Systematic Review and Meta-analysis on Attention Deficit Hyperactivity 
Disorder, Conduct Disorder, Autism Spectrum Disorder, and Autistic Disorder.   
Background Results
Methods
Conclusions
The estimated prevalence of ADHD to be
5.07% (3.49–6.92; 12 million cases);
prevalence of CD to be 1.34% (0.73–2.13; 3
million cases); prevalence of ASD to be
0.35% (0.18–0.56; 1 million cases); and
prevalence of AD to be 0.12% (0.07–0.17;
370,000 cases).
Results of meta-regression revealed that
geographical location was a risk factor
associated with variation in prevalence
estimates.
Results of sub group analysis shown in Fig 2.
Northeast region was associated with lower
prevalence of ADHD compared to north (B =
0.40, p < 0.01), east (B = 0.23, p < 0.01),
southcentral (B = 0.16, p < 0.05), and
northwest region (B = 0.40, p < 0.01).
Southwest region was significantly
associated with lower prevalence of ASD (B
= -0.08, p < 0.01), compared to northeast
region.
East and northwest region were
significantly associated with lower
prevalence of AD, compared with northeast
region (B = -0.03, p < 0.01; B = -0.02, p <
0.01).
Mental disorders are dominant health
problems for children and adolescents in
China. Previous systematic reviews on
childhood-onset mental disorders have
focused on country-level prevalence data in
China, and none of them quantified
difference in prevalence of childhood-onset
mental disorders by geographic regions.
Additionally, previous literatures addressed
the global data coverage indicated that there
are limited publications on population
representative data on childhood-onset
mental disorders in China. Notably, these
studies did not search any Chinese citation
database(s).
We took this opportunity
(1) To conduct searches on both the English
and Chinese language databases;
(2) To undertake meta-analyses on
childhood-onset mental disorders by
provincial, regional, and country levels;
in order to summarise the pooled prevalence
variations within China.
Four electronic databases were searched:
PubMed, EMBASE, PsycINFO, and China
National Knowledge Infrastructure (CNKI).
Childhood-onset mental disorders included
attention-deficit/hyperactivity disorder
(ADHD), conduct disorder (CD), autism
spectrum disorders (ASD), and autistic
disorder (AD), based on the Diagnostic and
Statistical Manual of Mental Disorders
(DSM), the International Classification of
Disease (ICD), or the Chinese Classification
of Mental Disorders (CCMD). We collected
articles reported diagnostic prevalence
estimates based on representative
population in China.
Meta-analysis was conducted weighting for
population size of the study location
represented according to the China
Statistical Yearbook 2017. Data coverage
was calculated by multiplying age proportion
and location proportion represented by each
study. Meta-regression was performed to
investigate whether or not geographic region
is a potential factor associated with variation
of the prevalence estimates.
Conflicts of Interest: none to declare
Our search identified 913 records, and 412
records were identified from CNKI. After
removal of duplicates and title, abstract full-
text screening, 59 studies were eligible for
final inclusion in this review, six were in
English, and 53 were in Chinese (Fig 1).
We derived estimates of the prevalence of
ADHD from 20 provinces, representing 9,54%
data coverage; prevalence of CD from 6
provinces, representing 4.47% data coverage;
prevalence of ASD for 11 provinces,
representing 2·44% data coverage; prevalence
of AD from 11 provinces, representing nearly
2·88% data coverage of population aged 0-19
years in China.
The provinces with the higher data coverage
for the four childhood-onset mental disorders
were municipalities such as Beijing, Tianjin,
and Shanghai. Conversely, there were 10
provinces which have no representative
prevalence data on childhood-onset mental
disorders since 1980. (Fig 3).
Figure 3: Data coverage (%) for childhood-onset 
mental disorders in 33 provinces in China
Figure 2: Estimated prevalence of childhood-onset 
disorders across 6 regions and China
Figure 1: PRISMA Flow Diagram
Our findings show large provincial and
regional variations in prevalence of ADHD,
CD, ASD, and AD across China. Furthermore,
the low data coverage reported in our results
has indicated an urgent need for researchers
to conduct more nationally or sub-nationally
representative surveys on these particular
mental disorders using rigorous
methodologies.


Childhood-onset Mental Disorders in 6 geographical regions in China: A Systematic Review and Meta-analysis on Attention Deficit Hyperactivity Disorder, Conduct Disorder, Autism Spectrum Disorder, and Autistic Disorder

https://espace.library.uq.edu.au/view/UQ:4d8e7d7/HuoCMSD_A0Poster.pdf

Childhood-onset Mental Disorders in 6 geographical regions in China: A Systematic Review and Meta-analysis on Attention Deficit Hyperactivity Disorder, Conduct Disorder, Autism Spectrum Disorder, and Autistic Disorder

Abstract

Similar works

Full text

Available Versions

University of Queensland eSpace