Postprocessing Neuroimaging methods in MRI and PET/MRI with applications to Multiple Sclerosis and other Neurological diseases

Abstract

Many non-invasive imaging instruments have been developed in the last 40 years, allowing to obtain images of the interior human body while the patient is still alive. In the contest of Neurology studies, imaging system as CT, MRI, SPECT or PET allows to obtain biomarkers useful to quantitatively distinguish between healthy and unhealthy subjects, evaluate the staging of a Neurological illness in a patient, evaluate the efficacy of a treatment, explore the causes of the illness. In this work MRI and PET imaging system introduced from scratch, going from reconstruction from raw data to state-of-the art post-processing techniques and the computation of more popular biomarkers. After these introduction, three original work using the recent PET/MRI imaging system are presented, with a particular focus on the methods. These three studies involve patients with Multiple Sclerosis, Alzheimer's Disease and Brain Tumor

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