Pain occurring in many patients suffering from cancer. Despite the currently available therapeutic methods,
many patients still suffer from bad pain control, especially in the advanced stages of the illness. In some
types of cancer, such as pancreatic cancer pain occurs in almost all patients. For many years now in clinical
practice is used the pharmacological treatment diagram suggested by WHO, according to which the selection
of analgesics is done according on the severity of pain. When pharmacological treatment is not sufficiently
effective advanced methods of treatment are used: local anesthesia techniques, destruction of the neural
structures were performed. In the present case of a patient with pancreatic cancer have been treated with
pharmacological methods, according to the severity of pain, in accordance with the treatment diagram. Due to the fact that not always the visceral pain can be effectively treated with pure mu opioid receptor
agonist, for this patient oxycodone were used. Main mechanism of action of oxycodone is related to the
stimulation of central and peripheral mu and kappa opioid receptors. Kappa opioid receptors are involved
in the mechanisms of visceral pain, and therefore the drug is highly effective in visceral pain. Because of
the concomitant diseases and their treatment invasive techniques were not possible. The efficacy of oxycodone
in visceral pain were confirmed in case of the patient with pancreatic cancer pain. The proposed
treatment, after the modification has brought pain relief without significant side effects
