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The effects of PPAR? and PPAR? agonists on proteinuria and oxidative stress in patients with type 2 diabetes mellitus
Authors
Balal M.
Cinkara Z.U.
+4 more
Inal T.
Kara E.
Paydas S.
Öztürk Ö.G.
Publication date
1 January 2017
Publisher
Scientific Publishers of India
Abstract
Objectives: In diabetes mellitus, renal-cardiovascular complications are important public health problems. We aimed to evaluate the effect of pioglitazone and fenofibrate, as PPAR agonists, on proteinuria and oxidative stress in diabetic patients. Patients and methods: 60 type 2 diabetic patients were included in this study. 15 patients with HbA1c7 and triglyceride350 mg/dl and HbA1c7 and triglyceride>350 mg/dl (GD). Biochemical tests, serum total oxidative status, paraoxonase-1 enzyme activity, C-reactive protein (CRP), brain natriuretic peptide (BNP), and spot urine protein/creatinine were measured at baseline (1), the 6th week (2) and the 12th week (3). The glomerular filtration rate (GFR) was also calculated. Results: In GB and GD, glucose (1) and HbA1c (1) were higher than glucose (2,3) and HbA1c (2,3) (p<0.05 for all). In GC and GD, triglycerides (1) were higher than triglycerides (2,3) (p<0.05 for all). Proteinuria, blood pressure, GFR, BNP, CRP, total oxidant status and paraoxonase-1 enzyme activity were not changed with pioglitazone and/or fenofibrate treatment. Conclusion: In contrast to blood glucose/triglyceride levels, pioglitazone and fenofibrate alone or in combination did not alter proteinuria, BNP, GFR, CRP, TOS or PON-1 enzyme activity during a period of 12 weeks in diabetic patients with different glucose or triglyceride levels. This could be related to the short study period and limited patient number. © 2017, Scientific Publishers of India. All rights reserved
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Last time updated on 06/02/2020