CORE
🇺🇦
make metadata, not war
Services
Services overview
Explore all CORE services
Access to raw data
API
Dataset
FastSync
Content discovery
Recommender
Discovery
OAI identifiers
OAI Resolver
Managing content
Dashboard
Bespoke contracts
Consultancy services
Support us
Support us
Membership
Sponsorship
Community governance
Advisory Board
Board of supporters
Research network
About
About us
Our mission
Team
Blog
FAQs
Contact us
The effects of N-methyl-d-aspartate receptor blockade during the early neurodevelopmental period on emotional behaviors and cognitive functions of adolescent wistar rats
Authors
Akillioglu K.
Binokay S.
+3 more
Kocahan S.
Polat S.
Sencar L.
Publication date
1 January 2013
Publisher
'Springer Science and Business Media LLC'
Doi
Cite
Abstract
PubMedID: 23462878The N-Methyl-d-Aspartate (NMDA) receptor is expressed abundantly in the brain and plays an important role in neuronal development, learning and memory, neurodegenerative diseases, and neurogenesis. In this study, we evaluated the effects of NMDA receptor blockade during the early neurodevelopmental period on exploratory locomotion, anxiety-like behaviors and cognitive functions of adolescent Wistar rats. NMDA receptor hypofunction was induced 7-10 days after birth using MK-801 in rats (0.25 mg/kg twice a day for 4 days via intraperitoneal injection). The open-field (OF), elevated plus maze (EPM) and passive avoidance (PA) tests were used to evaluate exploratory locomotion, anxiety-like behaviors and cognitive functions. In the OF test, MK-801 caused an increase in locomotion behavior (p 0.05). Chronic NMDA receptor blockade during the critical period of maturation for the glutamatergic brain system (postnatal days 7-10) produces locomotor hyperactivity and decreased anxiety levels, but has no significant main effect on cognitive function during adolescence. © 2013 Springer Science+Business Media New York.SYOBAP 2010/0002Acknowledgments This research was supported by Adiyaman University Research Fund (SYOBAP 2010/0002)
Similar works
Full text
Available Versions
Çukurova University Institutional Repository
See this paper in CORE
Go to the repository landing page
Download from data provider
oai:openaccess.cu.edu.tr:20.50...
Last time updated on 06/02/2020