Giriş: Ev tozu akarları bölgemizde en sık rastlanan inhalan allerjenlerdir. Bu çalışmada, persistan allerjik semptomları olan çocuklarda, Blomia tropicalis’e duyarlılık ve Dermatophagoides pteronyssinus ile arasındaki çapraz reaksiyon oranını araştırmayı amaçladık. Gereç ve Yöntem: Her iki akara olan duyarlılık, deri testi ve spesifik IgE düzeyleri ile değerlendirildi. Ayrıca, hem B. tropicalis hem de D. pteronyssinus’a duyarlı bulunan 38 hastaya her iki akar ile nazal ve bronşiyal provokasyonlar uygulandı. Bulgular: Persistan semptomları olan, astım ve/veya rinitli 165 çocuğa, D. pteronyssinus ve B. tropicalis ile deri testleri yapıldı ve spesifik IgE düzeyleri ölçüldü. Daha sonra, her iki akar ile toplam 46 nazal ve 30 bronşiyal provokasyon yapıldı. B. tropicalis’e duyarlılık, deri testleri ile %37.4, CAP ile %42.4 oranında saptandı. Yirmi üç hastaya D. pteronyssinus ile nazal provokasyon uygulandı ve tümü pozitif bulundu. B. tropicalis ile nazal provokasin 23 patients and all had positive results with D. pteronyssinus. 20 out of 23 (86.9%) patients had positive nasal challenges with B. tropicalis. Bronchial challenges were conducted in 15 patients and all of them had positive challenge with D. pteronyssinus except one. Twelve (80%) out of 15 patients had positive bronchial challenges with B. tropicalis. Conclusion: We found that the sensitization rate to B. tropicalis is not as high as D. pteronyssinus in our patients with persistent allergic symptoms. (Asthma Allergy Immunol 2011;9:20-28)Objective: House dust mites were found to be the most prevalent inhalant allergens in our region. We aimed to investigate the sensitization rate to Blomia tropicalis and to evaluate the cross-reactivity between Dermatophagoides pteronyssinus and B. tropicalis in children with persistent allergic symptoms. Materials and Methods: In order to determine the sensitization rate to these two mites, skin prick tests and specific IgE levels were used. Additionally, we performed nasal and bronchial challenges in a group of 38 patients who sensitized to both D. pteronyssinus and B. tropicalis. Results: Skin prick tests and specific IgE levels with D. pteronyssinus and B. tropicalis were performed in 165 children with asthma and/or rhinitis having persistent allergic symptoms. Then, a total of 46 nasal and 30 bronchial challenges were conducted with both mite species. The sensitization rate to B. tropicalis was found 37.4% using prick tests and 42.4% using CAP results. Nasal challenges were performe
