Comparison of bispectral index values in sevoflurane and sevoflurane-remifentanil administration in children

Abstract

Objective: This study was designed to compare the effects of remifentanil on anesthesia depth, sevoflurane consumption, hemodynamic parameters on children administered sevoflurane for general anesthesia. Method: 60 children aged 3-10 years were included and allocated to 2 groups. The anesthesia was induced with sevoflurane in nitrousoxide/oxygen in all children. Anesthesia was maintained with sevoflurane (Minimum alveolar concentration (MAC): % 0,5-2) in group I. In group II, 0,5 microgram/kilogram remifentanil was given for one minute, anesthesia was maintained with sevoflurane (MAC: % 0,5-2), 0,25 µg kg-1 h-1 remifentanil infusion. Sevoflurane concentration was titrated to be +/-20% of normal value of systolic, diastolic blood pressure and heart rate. Remifentanil infusion rate was kept constant in group II. Intraoperative bispectral index (BIS) values, heart rate, systolic, diastolic blood pressure, oxygen saturation, end tidal sevoflurane concentration, somatic reflexes (tears, sweating, cough, strain) were recorded every 15 minutes. Results: In all measurement, heart rates were lower in group II than group I (p<0,05). End tidal sevoflurane values were higher in group I than group II (p<0,001). BIS values were higher in group II than group I (p<0,05). Conclusion: Intravenous remifentanil infusion during sevoflurane anesthesia reduced end tidal sevoflurane concentration decreasing heart rate but did not influence BIS values. © 2018 Anestezi Dergisi. All rights reserved