It has been known for a long-time that neuroanatomical, neuroendocrinal and neurophysiological systems are sufficiently developed to allow transmission of painful stimuli in the neonate. But still many practitioners perform many procedures with no or minimal analgesia. One of the main reasons is the fear of adverse effects related to complications of analgesics. Endocrinometabolic and stress responses in newborn to invasive and surgical operations are more potent than adults. Newborns are regularly subjected to routine stressful and/or painful procedures every day in newborn intensive care units. It has been reported that the incidence of morbidity has increased in neonates subjected to severe and prolonged pain
