In the Department of haemostasis and thrombosis of the Institute of Blood Transfusion, Skopje, a method has been developed for the identification of immunoglobulin classes of HCV antibodies, the differentiation of immunoglobulin classes of HCV antibodies gives the possibility of identifying the acute type of HCV infection (only IgM type of HCV antibodies present) and the chronic type of HCV infection (both IgG and IgM type of HCV antibodies present).
Both the macro-and micro-ELISA system are employed in the immunoglobulin classes identification of HCV antibodies. The method we used is a double sandwich ELISA technique with the use of monospecific antisera for IgG and IgM
