Heterogeneous hardware is becoming increasingly available in modern hardware, while research breakthroughs enforce the expectation that heterogeneity will keep increasing in the future. Significant gains can be achieved via appropriate utilization of heterogeneity, in terms of performance and power consumption, however, poor utilization can have a detrimental effect. Intelligent scheduling and resource management is a crucial challenge we need to overcome in order to harvest the full potential of heterogeneous hardware. As systems become larger and include greater levels of hardware diversity, the importance of intelligent scheduling and resource management is further accentuated.This dissertation presents techniques that aid the process of scheduling and resource management in the presence of heterogeneous hardware, via accurately predicting upcoming runtime events. With a proactive and accurate view of the near future, schedulers can utilize the underlying hardware more efficiently, and fully take advantage of the available benefits.By adapting a majority element heuristic, this dissertation significantly improves the accuracy of predicting memory addresses about to be accessed, while reducing prediction-related costs by a factor of ten thousand compared to previously proposed predictive approaches. Coupled with novel microarchitectural modifications, accurate address predictions are shown to improve the performance of heterogeneous memory architectures.Machine learning-based performance predictors are further presented, capable of predicting a program's performance when executed on a given general-purpose core. Trained to model the subtleties of the interaction between hardware and software, these predictors are capable of generating highly accurate predictions even for cores with varied Instruction Set Architectures. Utilizing these performance predictions for job scheduling, is shown to improve overall system performance. The trained predictors are further examined and interpreted in order to visualize the correlations between features picked up and amplified during training.Finally, this dissertation demonstrates that scheduling algorithms cannot guarantee deriving an optimal schedule during realistic execution scenarios due to the underlying hardware heterogeneity, the wide range of runtime requirements of software, as well as prediction error from performance predictors. In response, deep neural networks are trained to select one scheduling approach from a list of options with varied overheads and correctness guarantees. The scheduling approach chosen, is the one which will most likely return the highest-performance schedule with the lowest overhead, given a particular instance of the job-to-core assignment problem
