Large cell calcifying Sertoli cell tumor (LCCST) is a rare testicular tumor, usually occurring
in young men before the age of 20. Ultrastructural study has been performed
rarely demonstrating Sertoli cell features. We report a case of LCCST in a 7-year-old
boy. A well-circumscribed yellowish-tan, 1.5-cm-sized mass was located within the
left testicular parenchyma. The cut surface was somewhat resilient with multiple calcifications.
On microscopic examination, the tumor was composed of large
eosinophilic polygonal cells with abundant eosinophilic cytoplasm arranging in solid
tubular and trabecular patterns, superficially mimicking Leydig cell tumor. However,
there were multiple calcifications and the tumor cell nests were surrounded by PASpositive
basement membrane. Ultrastructural examination revealed the features of
the Sertoli cell with Spangaro's crystals. The right testis showed a normal appearance
by ultrasonogram and there were no other clinical features associated with Carney
syndrome.ope