Calders, Patrick

Celie, Bert

Eloot, Sunny

Holvoet, Els

Van Biesen, Wim

Van Craenenbroeck, Amaryllis

Vanden Wyngaert, Karsten

English

Ghent University Academic Bibliography

METHODS: This monocentric study included patients on thrice weekly chronic on-line HDF. All patients received the classical dose of two tablets of Dialvit (containing50mg of thiamine, 10mg of riboflavin, 40mg of pyridoxine, 3mg of folic acid and200mg of vitamin C per tablet) after each dialysis session. Predialysis samples wereobained at baseline and concentrations of vitamin B1, B2, B5, B6, B8 and B9 and Cweremeasured in blood (all) and dialysate (subgroup). A second blood sample was obtainedin 24 patients three months after dose adjustment of the vitamin supplement.RESULTS: A total of 40 patients were recruited (mean age 56616 years, 25%women,40% diabetes, dialysis vintage 68months and weekly dialysis time 711627minutes). Atbaseline, the majority of patients were above the upper reference interval for allvitamins except for vitamin C, for whichmost patients were in the normal range. Threemonths after reduction to one tablet of Dialvit three times/week, vitamin levels werelower but mostly stayed above the normal range. However, three patients haddevelopped vitamin C deficiency on low dose substitution.Figure: Boxplots showing the pre-dialysis plasma concentrations of watersolublevitamins in 40 patients on hemodiafitration. Blue box: standard dose vitaminsubstition; red box: Lowered dose substitution. The upper and lower dashed linerepresent the reference interval.CONCLUSIONS: This monocentric study shows that the levels of most hydro-solublevitamins are above the normal range in patients on HDF receiving a classic dose ofvitamin supplements, vitamin C excepted.The actual dose of vitamin supplements can be safely lowered, with the exception ofvitamin C.FP745 ASSOCIATION BETWEEN GERIATRIC NUTRITION RISK INDEX,BONE MARROW DENSITY, BODY COMPOSITION ANDHANDGRIP STRENGTH IN PATIENTS RECEIVINGHEMODIALYSISHung-Chun Chen1, Pei-Yu Wu2, Jiun-Chi Huang3, Yi-Wen Chiu4, Jer-Ming Chang1, Szu-Chia Chen11Professor, Kaohsiung, Taiwan, 2Doctor, Kaohsiung, Taiwan, 3Assistant Professor,Kaohsiung, Taiwan and 4Associated Professor, Kaohsiung, TaiwanINTRODUCTION:Malnutrition occurs as a complication of hemodialysis (HD) andhas been identified as a risk factor for osteoporosis, sarcopenia and low physicalperformance. In this study, we assess the association between nutrition, bone marrowdensity (BMD), body composition and handgrip strength in HD patients.METHODS:We enrolled 164 patients with HDwho have received the dual energy X-ray absorptiometry (DXA) examination, categorized according to baseline geriatricnutritional risk index (GNRI) values calculated by serum albumin levels and bodyweight index. Besides, handgrip strength test was performed.RESULTS: Compared with those patients with tertile 1 of GNRI, patients with tertile 3of GNRI tend to have higher lumbar spine BMD and T-score, higher femoral neckBMD, higher total hip BMD, higher left distal 1/3 radius BMD and T-score, higher fatmass index, higher android/gynoid ratio, higher leanmass index and higher handgripstrength. An increase in GNRI tertile was associated with an increase of normal BMDand a decrease of osteoporosis prevalence. Low leanmass index and high parathyroidhormone were significantly associated with low BMD and T-score. In addition, highGNRI and high left distal 1/3 radius BMDwere significantly associated with highhandgrip strength.CONCLUSIONS:Our study demonstrated that good nutrition, indicated as highGNRI, had higher BMD and T-score, higher leanmass index and higher handgripstrength in HD patients. Using GNRI to evaluate nutritional status, and using DXA toinvestigate BMD and body composition in patients with HD is important to bonehealth and physical performance.FP746 ASSOCIATIONS BETWEEN THE MEASURES OF PHYSICALFUNCTION, THE RISK OF FALLS AND NUTRITIONAL STATUSOF HAEMODIALYSIS PATIENTS: A CROSS-SECTIONALSTUDYKarsten vanden Wyngaert1, Bert Celie1, Patrick Calders1, Sunny Eloot2,Els Holvoet2, Wim Van Biesen2, Amaryllis Van Craenenbroeck31Ghent University, Ghent, Belgium, 2Ghent University Hospital, Ghent, Belgium and3University of Antwerp, Antwerp, BelgiumINTRODUCTION: In uraemia, impairments in nutritional status and physicalfunction are common. Furthermore, protein-energy wasting (PEW) andmuscleweakness have been considered independent determinants of the risk of falls in patientson haemodialysis (HD).Whether PEW is related to other aspects of physical functionis unknown. The aim of this study was to evaluate the relation between PEW andmuscle strength, functional exercise capacity, and the risk of falls.METHODS: This cross-sectional multicentre study included consecutive HD patients.TheMini-Nutritional Assessment scale (MNA) as well as objective measures of PEWwere obtained (total iron-binding capacity, total protein levels, CRP, andhaemoglobin). Muscle strength (quadriceps and handgrip force), functional exercisecapacity (sit-to-stand and six-minute walking test (6MWT)), and the risk of falls(Tinetti, FICSIT-4, and dialysis fall index) were measured and analysed by generallinear models and logistic regression.RESULTS: 113 HD patients were enrolled (mean age 67 years6 16.1, 57.5%male) andamajority noted impairments in nutritional status (84.1%), quadriceps force (86.7%),6MWT (92%) and an increased risk of falls (73.5%). Measures of protein balance andinflammation explained 41% of the variance in the risk of falls (MNA, OR = 0.75;serum total protein, OR = 1.10; CRP, OR = 1.55). Remarkably, quadriceps weaknessshowed to be determined by haemoglobin levels (r = 0.39, OR = 0.54), independent ofEPO-supplementation and exercise capacity. No associations between PEW andfunctional exercise intolerance were found.CONCLUSIONS:Although the present study could not confirm a relation betweenmalnutrition andmuscle wasting on the one hand, and muscle weakness andfunctional exercise capacity on the other, malnutrition and the associated low-gradeinflammation were identified as determinants of the risk of falls.FP747 MOTOR FUNCTION AND PHYSICAL FRAILTY INHEMODIALYSIS PATIENTS WITH SEVERE OBESITYHe Zhou1, Fadwa Alali2, abdullah hamad2, Talal Talal2, Rania Ibrahim2, Baha ElHag3, Mincy Mathew2, Bijan Najafi11baylor medical college, houston, United States of America, 2Hamad General Hospital,Doha, Qatar, Qatar, 2Hamad General Hospital, Doha, Qatar and 3hamad general ,Doha, Qatar, QatarINTRODUCTION:Obesity is a common epidemic among patients with diabetes andend-stage renal disease undergoing hemodialysis (HD). It is well known that obesity isassociated with motor function decline in general population. On the other hand, inpatients with frailty symptom, because of muscle loss, the weight may reduce as well asmotor performance. In this study, we assumed that among HD patients with diabetes,obese patients may have better motor performance than non-obese patients.METHODS: Seventy-four HD patients with diabetes were recruited. Based on the BMIcutoff of 35 kg/m2or larger, 22 subjects were classified as severe obesity (Obese, age =62.96 7.3 years, BMI = 40.56 5.5 kg/m2, female=64%)and 52 subjects were classifiedas non-mild obesity (Non-Obese, age = 65.46 8.9 years, BMI = 27.66 3.8 kg/m2,female=46%). Gait parameters (stride velocity, stride length, gait cycle time, anddouble support) during habitual walking test and balance parameters (ankle, hip, andcenter of mass sways) during double-stance and semi-tandem balance tests werequantified using validated wearable platforms. Physical frailty status was assessed usingFried Frailty Criteria.doi:10.1093/ndt/gfz106 | i301Nephrology Dialysis Transplantation AbstractsDownloaded from https://academic.oup.com/ndt/article-abstract/34/Supplement_1/gfz106.FP746/5515414 by Ghent University user on 06 January 2020

Associations between the measures of physical function, the risk of falls and nutritional status of haemodialysis patients : a cross-sectional study

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Associations between the measures of physical function, the risk of falls and nutritional status of haemodialysis patients : a cross-sectional study

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