Croatian Veterinary Association/Chamber, University of Zagreb Faculty of Veterinary Medicine
Abstract
Ozon je vrlo nestabilan plin građen od tri atoma kisika u mezomeričkoj strukturi. U prirodi je slobodno prisutan u stratosferi, a uloga mu je štititi površinu zemlje od štetnog djelovanja ultraljubičastih zraka. Ozon aktivira imunosni sustav, ponajprije lokalno na mjestu kontakta sa sluznicama, poticanjem proizvodnje interferona i interleukina, povećanjem razine glutation-peroksidaze, katalaze i superoksid-dismutaze, te aktivirajući neutrofile i sintezu citokina. Potvrđeno je baktericidno, fungicidno i virucidno djelovanje ozona u kontaktu sa spomenutim mikroorganizmima, a djeluje prije svega oksidacijom fosfolipida i lipoproteina stanične stjenke. Opisano je i snažno analgetsko djelovanje nakon rektalne insuflacije i aplikacije u akupunkturne točke. Zbog navedenih svojstava našao je uporabu u medicini te se rabi za liječenje raznih upalnih stanja i prevenciju postoperativnog bola. Ipak, najširu upotrebu u veterinarskoj medicini ozon je našao u liječenju upalnih stanja spolnog sustava u krava.Ozone is a highly unstable gas composed of three oxygen atoms in a mesomeric state. It is freely present in nature only in the stratosphere, where it protects the Earth’s surface from ultraviolet light. Ozone activates the immune system, primarily locally on the contact surface, by activating production of interferon and interleukin, by increasing the level of glutathione peroxidase, catalase and superoxide dismutase, as well as by activating neutrophils and cytokine synthesis. Bacteria, spores, and viruses are inactivated by ozone in their contact via the process of oxygenation of phospholipid and lipoproteins within the cell membrane. The strong analgesic activity of ozone following rectal insufflation or insufflation into acupuncture points is also known. However, the most widespread use of ozone within the field of veterinary medicine is for treatment of various pathological conditions of the genital system in dairy cows
