A Bertolino

A Carlsson

A Demjaha

A Di Martino

A Egerton

A Meyer-Lindenberg

A Parent

A Stepanyants

A Vita

AA Grace

AC Roberts

AC Tziortzi

AE Cullen

AL Guillozet-Bongaarts

AM Morales

AR Braun

AT Ferry

AY Deutch

B Draganski

BJ Kinon

C Colantuoni

C Kellendonk

C Studholme

CC Lin

CJ Pycock

D Joel

D Martinez

D Sun

DB Carr

DB Chklovskii

DK Sarpal

DR Weinberger

E Bora

E Kim

E Mouchlianitis

E Plitman

Enrico D’Ambrosio

Euitae Kim

F Caravaggio

FE Turkheimer

Federico Turkheimer

Fiona Pepper

G Flores

G Gründer

G Modinos

G Rajkowska

GE Alexander

GE Jaskiw

HA Whiteford

IB Malone

IH Kim

Ilaria Bonoldi

J Ashburner

J Barnes

J Busner

J Frank

J Perälä

JA Lieberman

JA Maldjian

JE Hoover

JP Lindenmayer

Jun Soo Kwon

K Nakano

KF Casey

KJ Werhahn

KL Davis

LD Selemon

LS Kegeles

M Alessandrini

M Avram

M Guttman

M Heslin

M Sajatovic

M. E. Goldstein

MA Bloomfield

Maria Rogdaki

Matthew J. Kempton

Mattia Veronese

MC Reddan

N Jaworska

NC Andreasen

ND Woodward

NJ Breitborde

NV Kraguljac

O Howes

OD Howes

English

Sameer Jauhar

Seoyoung Kim

Vasileia Kotoula

Oliver D. Howes

SP Brugger

Q Gong

Y Hirayasu

P Fusar-Poli

R Mizrahi

R McCutcheon

S Leucht

RS Kahn

S Kapur

P Cumming

SN Haber

Y Kumakura

S Jauhar

RC Roberts

P Allen

Crossref

The relationship between grey matter volume and striatal dopamine function in psychosis: a multimodal 18F-DOPA PET and voxel-based morphometry study

A leading hypothesis for schizophrenia and related psychotic disorders proposes that cortical brain disruption leads to subcortical dopaminergic dysfunction, which underlies psychosis in the majority of patients who respond to treatment. Although supported by preclinical findings that prefrontal cortical lesions lead to striatal dopamine dysregulation, the relationship between prefrontal structural volume and striatal dopamine function has not been tested in people with psychosis. We therefore investigated the in vivo relationship between striatal dopamine synthesis capacity and prefrontal grey matter volume in treatment-responsive patients with psychosis, and compared them to treatment non-responsive patients, where dopaminergic mechanisms are not thought to be central. Forty patients with psychosis across two independent cohorts underwent 18F-DOPA PET scans to measure dopamine synthesis capacity (indexed as the influx rate constant Kicer) and structural 3T MRI. The PET, but not MR, data have been reported previously. Structural images were processed using DARTEL-VBM. GLM analyses were performed in SPM12 to test the relationship between prefrontal grey matter volume and striatal Kicer. Treatment responders showed a negative correlation between prefrontal grey matter and striatal dopamine synthesis capacity, but this was not evident in treatment non-responders. Specifically, we found an interaction between treatment response, whole striatal dopamine synthesis capacity and grey matter volume in left (pFWE corr. = 0.017) and right (pFWE corr. = 0.042) prefrontal cortex. We replicated the finding in right prefrontal cortex in the independent sample (pFWE corr. = 0.031). The summary effect size was 0.82. Our findings are consistent with the long-standing hypothesis of dysregulation of the striatal dopaminergic system being related to prefrontal cortex pathology in schizophrenia, but critically also extend the hypothesis to indicate it can be applied to treatment-responsive schizophrenia only. This suggests that different mechanisms underlie the pathophysiology of treatment-responsive and treatment-resistant schizophrenia.</p

D'Ambrosio, Enrico

Jauhar, Sameer

Kim, Seoyoung

Veronese, Mattia

Rogdaki, Maria

Pepper, Fiona

Bonoldi, Ilaria

Kotoula, Vasileia

Kempton, Matthew J

Turkheimer, Federico

Kwon, Jun Soo

Kim, Euitae

Howes, Oliver D

King's Research Portal

The relationship between grey matter volume and striatal dopamine function in psychosis:a multimodal 18F-DOPA PET and voxel-based morphometry study

https://kclpure.kcl.ac.uk/portal/files/121449178/DAmbrosio_Jauhar_MolPsych_2019.pdf

The relationship between grey matter volume and striatal dopamine function in psychosis:a multimodal 18F-DOPA PET and voxel-based morphometry study

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King's Research Portal