An SQ

Andrewes AG

Barber CE

Bradbury JF

Chatterjee S

Christensen P

Colnaghi Simionato AV

Dow JM

Folman LB

Fuqua C

Giesler LJ

He YW

Jenkins CL

Li SJ

Liu YR

Loh J

Lou LL

Patankar AV

Qian GL

Ryan RP

Schaad NW

Slater H

Xie YX

Zhou L

ABSTRACT
          
            Lysobacter enzymogenes
            is a ubiquitous environmental bacterium that is emerging as a potentially novel biological control agent and a new source of bioactive secondary metabolites, such as the heat-stable antifungal factor (HSAF) and photoprotective polyene pigments. Thus far, the regulatory mechanism(s) for biosynthesis of these bioactive secondary metabolites remains largely unknown in
            L. enzymogenes
            . In the present study, the diffusible signal factor (DSF) and diffusible factor (DF)-mediated cell-cell signaling systems were identified for the first time from
            L. enzymogenes
            . The results show that both Rpf/DSF and DF signaling systems played critical roles in modulating HSAF biosynthesis in
            L. enzymogenes
            . Rpf/DSF signaling and DF signaling played negative and positive effects in polyene pigment production, respectively, with DF playing a more important role in regulating this phenotype. Interestingly, only Rpf/DSF, but not the DF signaling system, regulated colony morphology of
            L. enzymgenes
            . Both Rpf/DSF and DF signaling systems were involved in the modulation of expression of genes with diverse functions in
            L. enzymogenes
            , and their own regulons exhibited only a few loci that were regulated by both systems. These findings unveil for the first time new roles of the Rpf/DSF and DF signaling systems in secondary metabolite biosynthesis of
            L. enzymogenes
            .
          </jats:p

Guoliang Qian

Yulan Wang

Yiru Liu

Feifei Xu

Ya-Wen He

Liangcheng Du

Vittorio Venturi

Jiaqin Fan

Baishi Hu

Fengquan Liu

Crossref

Applied and Environmental Microbiology

Lysobacter enzymogenes Uses Two Distinct Cell-Cell Signaling Systems for Differential Regulation of Secondary-Metabolite Biosynthesis and Colony Morphology

Lysobacter enzymogenes Uses Two Distinct Cell-Cell Signaling Systems for Differential Regulation of Secondary-Metabolite Biosynthesis and Colony Morphology

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