Freeman, David S.

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University of Montana

University of MontanaScholarWorks at University of MontanaSyllabi Course SyllabiSpring 1-2003PHAR 328.01: Antimicrobial AgentsDavid S. FreemanUniversity of Montana - MissoulaLet us know how access to this document benefits you.Follow this and additional works at: https://scholarworks.umt.edu/syllabiThis Syllabus is brought to you for free and open access by the Course Syllabi at ScholarWorks at University of Montana. It has been accepted forinclusion in Syllabi by an authorized administrator of ScholarWorks at University of Montana. For more information, please contactscholarworks@mso.umt.edu.Recommended CitationFreeman, David S., "PHAR 328.01: Antimicrobial Agents" (2003). Syllabi. 4290.https://scholarworks.umt.edu/syllabi/4290PHARMACY 328 (ANTIMICROBIAL AGENTS) SPRING SEMESTER, 2003INSTRUCTOR: David Freeman, Office - SB 308 Office Phone: 243-4772 Home Phone: 728-6551 E-mail: dfreeman@selwav.umt.eduEXAMS AND GRADING:First Exam: Tuesday, MARCH 4  50 pointsSecond Exam: Thursday, APRIL 3  70 pointsThird Exam: Thursday, MAY 1  80 pointsFinal Exam:  100 points10 Point Quizzes: Best 5 or 6 out of 6 scores . . 50 or 60 pointsTotal Points: 350, or 360 90-100% = A 80-89 % = B 70-79 % = C 65-69 % = D* All EXAMS are comprehensive* All exams and quizzes must be taken at scheduled times* Instructor must be informed BEFORE missing a scheduled exam period and MUST be based on GOOD REASONS* Missed exam periods must be made up within 2 days* No make up quizzesSTUDENT PERFORMANCE OBJECTIVES:1) Know the normal relevant biochemical pathways and the major biochemical mechanismsof action for the different classes of drugs2) Know the biochemical mechanisms involved in the development of resistance to differentclasses of antimicrobial agents3) Given a representative chemical structure or name of a drug, know its biochemical mechanismsof action and for development of resistance4) Given a representative chemical structure or name of a drug, know its major chemical,pharmacologic, or therapeutic categorization5) Given a representative chemical structure or name of a drug, know its majortherapeutic uses and spectrum of activity6) Given a representative chemical structure or name of a drug, know important aspects of itsabsorption, pharmacokinetics, and metabolism7) Know important chemical features (i.e., polar or lipophilic properties, labile groups, etc.) thataffect the absorption, distribution, metabolism, elimination, potency, stability, or formulation of a class of antimicrobial agents8) Given the chemical structure of an antimicrobial agent, know important chemical changesthat will predictably alter its properties (i.e., potency, duration of action, stability, etc.)9) Given a representative chemical structure or name of a drug, know its most common or seriousadverse or side effectsREQUIRED TEXT: Goodman & Gilman, "The Pharmacological Basis of Therapeutics", Tenth EditionReading in Text1143-1159 I. General Considerations, Categorization, andTable 43-1 Sensitivity Testing of Antimicrobial AgentsThe following areas will be covered for each outline topic below:-General Chemical Structures and Properties of Agents -Biochemical Mechanisms of Action for Agents-Biochemical Mechanisms Involved in the Development of Microbial Resistance -Important Aspects of Absorption, Distribution, Metabolism, and Elimination for Agents -Antimicrobial Spectrum of Activity for Agents -Important Adverse Effects and Drug Interactions for AgentsReadingin TextII. Antibacterial Agents1171-1179 A. Sulfonamides and TRIMETHOPRIM1179-1183 B. Quinolones, Fluoroquinolones1184-1185 C. NITROFURANTOIN and METHENAMINED. Beta-lactam Antibiotics1189-1205 1. Penicillins1214-1215 2. Beta-lactamase inhibitors (CLAVULANIC ACID, SULBACTAM, TAZOBACTAM)1206-1213 3. Cephalosporins1213-1214 4. Carbapenems (IMIPENEM), Carbacephems (LORACARBEF),Monobactams (AZTREONAM)1261-1266 E. SPECTINOMYCIN, POLYMYXIN, VANCOMYCIN, TEICHOPLANIN, BACITRACIN1219-1234 F. Aminoglycosides1239-1246 G. Tetracyclines1250-1256 H. Macrolides (ERYTHROMYCIN, AZITHROMYCIN, CLARITHROMYCIN)1246-1250 I. CHLORAMPHENICOL 1256-1258 J. CLINDAMYCIN1258-1259 K. Streptogramins (QUINUPRISTIN, DALFOPRISTIN)1260-1261 L. Oxazolidinones (LINEZOLID)1105-1108 M. METRONIDAZOLEIII. Anti-mycobacterial Agents1273-1282 A. Drugs for Tuberculosis* ISONIAZID RIFAMPIN PYRAZINAMIDE ETHAMBUTOL *B. Drugs for Mycobacterium Avium Complex1286-1288IV. Antifungal AgentsA. AMPHOTERICIN B and FLUCYTOSINEB. Imidazole and Triazole Antifungal Agents (azoles)* KETOCONAZOLE ITRACONAZOLE FLUCONAZOLE VORICONAZOLE *1305-1306 C. GRISEOFULVIN and TERBINAFINE and CASPOFUNGIN1307-1310 D. Topical Antifungal Agents* CLOTRIMAZOLE MICONAZOLE TOLNAFTATE NAFTIFINE ** NYSTATIN UNDECYLENIC ACID *V. Antiviral Agents1313-1317 A. Overview of Viral DNA and RNA Biochemical Processes1295-13001301-1305B. Overview of Biochemical Mechanisms of Action and Resistance DevelopmentC. Non-HIV Antiviral Agents* ACYCLOVIR VALACYCLOVIR CIDOFOVIR DOCOSANOL ** FAMCICLOVIR PENCICLOVIR FOSCARNET GANCICLOVIR** VALGANCICLOVIR TRIFLURIDINE VIDARABINE *1329-1332 D. Antiinfluenza Agents * AMANTADINE RIMANTIDINE OSELTAMIVIR ZANAMIVIR *1332-1340 E. Other Antiviral Agents1317-13191317-1328VI. HIV Antiviral AgentsA. Overview of HIV InfectionB. Nucleoside Reverse Transcriptase Inhibitors * ZIDOVUDINE DIDANOSINESTAVUDINE ZALCITABINE LAMIVUDINE ABACAVIR TENOFOVIR *C. Nonnucleoside Reverse Transcriptase Inhibitors* NEVIRAPINE DELAVIRDINE EFAVIRENZ *D. Protease Inhibitors* SAQUINAVIR INDINAVIR RITONAVIR NELFINAVIR AMPRENAVIR*1349-13531353-13601360-13631364-13731076, 1109-1111E. Drugs for Opportunistic Infections* ATOVAQUONE PENTAMIDINE *

PHAR 328.01: Antimicrobial Agents

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PHAR 328.01: Antimicrobial Agents

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