Błazińska, Р.

Korolevich, V.

Sykuła, A.

Łodyga-Chruścińska, E.

Błazińska, P.

Repository of Polessky State University (Репозиторий Полесского государственного университета)

110  НАУЧНЫЕ И ПРИКЛАДНЫЕ АСПЕКТЫ  РАЦИОНАЛЬНОГО ИСПОЛЬЗОВАНИЯ  ПРИРОДНЫХ РЕСУРСОВ    NOVEL THIOCARBOHYDRAZONE DERIVATIVE OF FLAVANONE  Błazińska Paulina1, MSc BSc, PhD Student Korolevich Violetta2, MSc BSc, PhD Student Sykuła Anna1, PhD MSc, Assistant Professor Łodyga–Chruścińska Elżbieta1, Prof. PhD MSc BSc, Professor 1Lodz University of Technology 2Polessky State University  Polyphenols are a category of chemicals that naturally occur in plants. They are known as phytochemicals. These chemicals can be categorized into the following groups: flavonoids, phenolic acids, stilbenes and lignans. The largest group of polyphenols are flavonoids which are widely spread in nature. The main class of polyphenolic secondary metabolites are flavanones. They are very interesting compounds extensively present in food products of plant origin for example citrus fruits. Derivatives of flavanone with substituents in rings: A or B have various and valuable properties, such as anti–inflammatory, antimicrobial, antioxidant, or antitumor. The basic moiety of these compounds is flavanone (Fig. 1) [1,2]   76584 32O1'6'5'4'3'2'OA CB Figure 1 – Chemical structure of flavanone  Their bioavailability and bioactivity depends on chemical structure. They have huge and significant  potential in the treatment of many illnesses like cancer or cardiovascular diseases [3]. Thiocarbohydrazides are also really important class of chemical compounds that have applications in organic chemistry, biology and medicine due to their valuable reactions and variety of activities. The aromatic derivatives of thiocarbohydrazide exhibit high antiviral and antimicrobial activity. [4] ПолесГУ111  Thiocarbohydrazide Schiff bases are chemical compounds of great importance in medicine and pharmacy. Due to their crucial role in these areas they could be used as potential drugs. It is very promising field of science. [4] The aim of work was synthesized new derivative of flavanone and thiocarbohydrazide (Fig.2)  and analyzed by different spectral methods like UV–visible, IR and NMR spectra.  NNHSNHNOO  Figure 2 – Chemical structure of thiocarbohydrazone derivative of flavanone FTCH (N'–((E)–2–phenylchroman–4–ylidene)–2–((Z)–2–phenylchroman–4– ylidene)hydrazine–1–carbothiohydrazide)  The results showed that the application of spectroscopic methods NMR, IR and UV confirm structure of new compound FTCH. FTCH will be used for further studies to investigate biological activity.  The list of references 1. Update on uses and properties of citrus flavonoids: new findings in anticancer, cardiovascular, and anti–inflammatory activity / O. Benavente–García, J. Castillo //  Journal of Agricultural and Food Chemistry. – Washington, 2008. – V.  56 (15). – P. 6185–6205. 2. A comprehensive review on flavanones, the major citrus polyphenols / M. K. Khan, Z. E Huma, O. Dangles // Journal of Food Composition and Analysis. – Amsterdam, 2014. –  V. 33. – P. 85–104.  3. Flavanone and 2'–OH flavanone inhibit metastasis of lung cancer cells via down–regulation of proteinases activities and MAPK pathway / Y.C. Hsiao, W.H. Kuo, P.N. Chen, H.R. Chang, T.H. Lin, W.E. Yang, Y.S. Hsieh, S.C. Chu // Chemico–Biological Interactions. – Amsterdam, 2007. V. 167. – P. 193. 4. Metal complexes of thiosemicarbazones for imaging and therapy / J.R. Dilworth, R. Hueting // Inorganica Chimica Acta. – Amsterdam, 2012. – V. 389. – P. 3–15.    ПолесГУ

NOVEL THIOCARBOHYDRAZONE DERIVATIVE OF FLAVANONE

https://rep.polessu.by/bitstream/123456789/14203/1/B%c5%82azi%c5%84ska%20P.%20Korolevich%20V.%2c%20Syku%c5%82a%20A.%2c%20%c5%81odyga%e2%80%93Chru%c5%9bci%c5%84ska%20E..pdf

NOVEL THIOCARBOHYDRAZONE DERIVATIVE OF FLAVANONE

Abstract

Similar works

Full text

Available Versions

Repository of Polessky State University (Репозиторий Полесского государственного университета)