The problem of oxybarotherapy of uterine infertility was proposed as a proposition of a safe complementary method of fertility improvement. The possibilities of using hyperbaric therapy and new directions of its application have been presented. Indications of hyperbaric therapy are constantly modified and new fields of its applications are noticed. A project for the use of aerobic hyperbole in the world was described and the possibility of implementing therapy to Poland was indicated. The benefits of supplementary therapy, which is oksybaroterapy in the treatment of couples with impaired uterine fertility, are presented

Dzięgielewski, Piotr

Olszański, Romuald

Sas, Katarzyna

Zieliński, Ewa

Zukow, Walery

Journal of Education Health and Sport

English

Ewa Zieliński

Piotr Dzięgielewski

Katarzyna Sas

Romuald Olszański

Walery Zukow

Directory of Open Access Journals

Zieliński  Ewa,  Dzięgielewski  Piotr,  Sas  Katarzyna,  Olszański  Romuald,  Zukow Walery.  Oxybarotherapy  of  uterine  infertility.Journal of Education, Health and Sport. 2018;8(12):262-268. eISNN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.2222348http://ojs.ukw.edu.pl/index.phpohs/article/view/6372The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part B item 1223 (26/01/2017).1223 Journal of Education, Health and Sport eISSN 2391-8306 7© The Authors 2018;This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, PolandOpen Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium,provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license Share alike.(http://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited.The authors declare that there is no conflict of interests regarding the publication of this paper.Received: 10.11.2018. Revised: 20.11.2018. Accepted: 12.12.2018.Oxybarotherapy of uterine infertilityOxybaroterapia niepłodności maciczopochodnejEwa Zieliński1, Piotr Dzięgielewski2, Katarzyna Sas3,Romuald Olszański4, Walery Zukow51Department of Emergency Medicine and Catastrophe Medicine of Collegium Medicum in Bydgoszcz,University of Mikołaj Kopernik in Toruń, Poland2SPZOZ 10 Military Clinical Hospital with Policlinics in Bydgoszcz, Poland3Department and Division of Pedagogics and Nurse Didactics of Collegium Medicum in Bydgoszcz,Mikołaj Kopernik University in Toruń, Poland4Department  of Maritime and Hyperbaric Medicine, Military Medical Institute of Gdynia, Poland5Department of Spatial Management and Tourism, Faculty of Earth Sciences,Nicolaus Copernicus University in Torun, Torun, PolandSłowa kluczowe: hiperbaria, choroby, niepłodnośćKey words: hyperbaria, disease, infertilityAbstraktW pracy podjęto problem  Oxybaroterapii  niepłodności  maciczopochodnej,  jako propozycjibezpiecznej  uzupełniającej  metody  poprawy  płodności.  Przedstawiono  możliwości  zastosowaniahiperbarii  tlenowej  i  nowe  kierunki  jej  zastosowania.  Wskazania  terapii  hiperbarycznej  są  stale262modyfikowane i dostrzega się nowe pola jej zastosowań. Opisano projekt wykorzystania hiperabriitlenowej na świecie i wskazano na możliwość zaimplementowania terapii do Polski. Przedstawionokorzyści wynikające z zastosowania terapii uzupełniającej, jaką jest hiperbaria tlenowa w leczeniu parz upośledzona płodności maciczozależną.AbstractThe problem of oxybarotherapy of uterine infertility was proposed as a proposition of a safecomplementary method of fertility improvement. The possibilities of using hyperbaric therapy andnew directions of its application have been presented. Indications of hyperbaric therapy are constantlymodified and new fields of its applications are noticed. A project for the use of aerobic hyperbole inthe world was described and the possibility of implementing therapy to Poland was indicated. Thebenefits of supplementary therapy, which is oksybaroterapy in the treatment of couples with impaireduterine fertility, are presented.IntroductionInfertility (sterilitas) is defined by the World Health Organization (WHO) as beingunable to get pregnant despite having regular sexual intercourse (4-5 a week), maintained formore  than  12  months  without  using  any  contraceptive  methods.  Women who  experiencedifficulty in getting pregnant often feel depressed, which can lead to depression 1. The scale ofthis phenomenon in our country is based on estimates obtained from studies and research ofthe European Society of Human Reproduction and Embryology (ESHRE), 10-15% of couplesare estimated to be infertile in Poland which allows to conclude that it affects about 1 millionPolish marriages in reproductive age. For comparison, in America it is as many as six millioncouples. In addition, it also turns out that only 19% of infertile couples seek specialist medicalhelp. Appropriate preparation of the endometrium during the menstrual cycle is necessary forconception,  due  to  its  role  in  embryo  implantation.  In  fact,  implant  failure  is  the  mostcommon problem associated with in vitro fertilization. Endometrium thickness of the 10mm isconsidered the most beneficial for the implantation of a fertilized egg. With a thickness of 7mm or less, implantation of the fertilized egg is unlikely. Women are then advised to take highdoses of estrogen or use other pharmacological substances, such as pentoxifylline, to increaseperipheral blood flow. However, many women not only suffer the negative effects of hormonetherapy but also discontinue therapy, fearing fetal damage.1 V. Skrzypulec, K.Nowosielski, A. Drosdzol, R. Kowalaczyk. Endokrynologia Polska 2005; 6(56): 964-969.263Oxybarotherapy in the treatment of uterine infertilityOxybarotherapy can bring beneficial therapeutic effects. Hyperbaric oxygen therapydeals  with  the  impact  of 100% pure  oxygen  on  the  body in  the  conditions  of  increasedatmospheric pressure 2. Hyperbaric oxygen therapy is the delivery of increased oxygen todamaged tissues and organs.  Under normobaric conditions, plasma transports only 0.0003ml of oxygen per liter of blood, while with the supply of 100% oxygen in the hyperbaricchamber, this value increases up to 0.68 ml3. Oxybarotherapy in some diseases is used as thebasic form of therapy, while in the majority of others it is treated as a supportive or alternativetreatment 4.Hyperbaric oxygen therapy is a safe and very effective adjuvant therapy for womenapplying for treatment of uterine infertility which means with insufficient thickness of theendometrium. In order to improve the factors contributing to the increase of the chance ofimplantation  of  a  fertilized  egg,  women  undergo  hyperbaric  oxygen  therapy.  Hyperbaricoxygen  therapy  has  been  shown  to  improve  uterine  blood  supply  and  thickness  of  theendometrium. Recent medical research conducted at a research center in Serbia showed goodresults  in  the  increase  of  the  tickness  of  endometrium during  treatment  in  a  hyperbaricchamber.  The results  of  treatment  of  uterine  infertility  and male  infertility  research  frominternational research centers are presented below.Treatment of uterine infertility using oxygen hyperbaric therapy in the worldAt University Hospital for Gy and OB, Narodni front, School of Medicine, Univerisity ofBelgrade, Serbia, 32 patients were treated in a multi-seat hyperbaric chamber at 2.1 to 2.3ATA for 70 minutes,  7-10 days in sequence from day 2 to 5 of the menstrual cycle.  Theevaluation of effects of hyperbaric oxygen therapy has been carried out. An improvement inoxygenation  and blood supply  of  the  uterus,  better  response of  stimulated  ovaries,  betterquality of embryos and higher pregnancy rate has been noticed5. An increase in the thicknessof the endometrium, on average up to 11 mm, was found. The thickness of the endometriumduring  ovulation after  hyperbaric  treatment  has  tripled.  It  was  noted that  the  endometrialthickness effect was sustained in the next monthly menstrual cycle. Doppler examination ofuterine arteries and vascular mapping after applying hyperbaric oxygen therapy showed theformation of  new  capillaries  of  the  endometrium,  especially  after  4-6  weeks  after  HBOtherapy. Oxygen used at higher pressure seems to have a beneficial effect on achieving abetter  result  of  pregnancy  implantation  by  improving  endometrial  susceptibility  forimplantation, which makes hyperbaric oxygen therapy considered as the treatment of choice6.2 A. Sieroń, G. Cieślar, Zarys medycyny hiperbarycznej, wyd. II α-medica 2007 Bielsko-Biała, s. 23.3 Ibidem4 Ibidem5 A.M. Jovanovic. Hyperbaric Oxygenation Therapy in Infertility Patients. Crit Care Obst & Gyne. 2016, 2:1. doi:10.21767/2471-9803.100012.6 Ibidem264Treatment of male infertility using oxygen hyperbaric therapy in the worldAt the University of Belgrade, patients with male sterility were also treated. In thisgroup,  also  as  a  result  of  identical  hyperbaric  treatment,  after  two  months  of  treatmentincreased  spermatogenesis  was  noted.  The  results  obtained  suggest  a  beneficial  effect  ofhyperbaric  oxygen  therapy  on  the  viability  and  motility  of  sperm.  Prolongation  andpostponement of hyperbaric oxygen therapy effects  were verified by spermiogram- semenanalysis after 70 to 90 days after the end of treatment with results of good spermatogenesisinduction  thanks to  elimination  of  reactive  oxygen species  and avoiding infection  due tohyperoxia.7An application of the oxygen hyperbaric treatment of infertility in the worldThere are many factors that affect the fertility of women and men and the chance ofbecoming  pregnant.  The  Belgrade  Clinic's  experience  clearly  indicates  that  combinedhormone therapy and hyperbaric therapy have a positive effect on infertility treatment and canincrease the chance of having children.DiscussionFor a long time the prevailing view is that medically assisted procreation proceduresrequire the adoption of relevant laws and the introduction of functional institutional solutions.It is also underlined that these regulations should ensure a high level of applied procedures,respect the rights and protect the interests of the persons being treated and take into accountthe well-being of children born after applying infertility treatment techniques8.According to  the World Health Organization (WHO), disease is  a denial  of health  andhealth  is  a  state  of  complete  physical,  mental  and  social  well-being  and  not  merely  theabsence  of  disease  or  infirmity.  After  adapting  this  definition  on  International  Conference  ofPopulation and Development in Cairo, this definition was expanded for reproductive health as: a stateof full  physical, mental and social well-being in all matters related to the reproductive system9. Itshould be added that the WHO not only counts infertility to diseases in the general sense ofthe word but also postulates to include it as a social disease, that is, to a group of diseases thatare widespread, chronic, difficult to cure, requiring long, regular medical care, limiting humanability to perform basic life tasks, which are a big problem not only for the individual but alsofor the whole society10, 11, 12, 13.7 Ibidem8 Por.  m.in.  Założenia  regulacji  prawnej  dotyczącej  wspomaganej  medycznie  prokreacji,  stanowiskokońcowe sformułowane przez grupę ekspertów biorących udział w pracach tzw. Komisji Gowina w osobach:prof. dr hab. E. Bartnik, prof. dr hab. J. Hołówka, prof. dr hab. Z. Szawarski, prof. dr hab. J. Zaremba, prof. drhab. E. Zielińska, Warszawa, październik 2008 r. (dalej: stanowisko ekspertów).9 E. Zielińska: Opinia sporządzona 21  maja 2015  r. na zlecenie Biura Analiz Sejmowych (druk sejmowynr 3245/VII  kad.); na  temat  rządowego  projektu  ustawy  o leczeniu  niepłodności;  Zeszyty  Prawnicze  BiuraAnaliz Sejmowych Kancelarii Sejmu nr 4(48) 2015 s. 183–19610 Por.  szerzej  C.  Łepecka-Klusek,  A.B.  Pilewska-Kozak,  Niepłodność  w świetle  definicji  chorobypodanej przez WHO, „Medycyna Ogólna i Nauki o Zdrowiu” 2012, t. 18, nr 2, s. 162–165 oraz wskazane tammateriały źródłowe.265Assuming that in vitro fertilization is one of the infertility treatment accepted in thelight of the current state of medical knowledge, it may be considered whether it would beadvisable  to  introduce  a  modern  method  of  hyperbaric  oxygen  therapy  into  the  clinicalprocedures for supporting the treatment of one of the forms of infertility - uterine infertility.According to the authors of this report, it brings social and medical benefits.  In this type ofinfertility  it  is  possible  to  achieve  high  treatment  results  by  combining two conventionalmethods  of  treatment:  hormonal  stimulation  and  hyperbaric  oxygen  therapy.  Currently,hormonal treatment is a recognized and widely used in the world (also in Poland) method ofinfertility treatment but not always bringing satisfactory results. As the first reports indicate,the use of hyperbaric oxygen therapy to support traditional treatment may determine a newquality of infertility treatment.ConclusionThe use of hyperbaric oxygen therapy and its indications are evaluated. New trends inHBOT therapy are  noticed.  Unfortunately,  in  the  literature  there  is  a  deficit  of  scientificstudies  that  address  the  described  medical  problem.  Available  scientific  reports  are  verypromising but still insufficient. Scientific reports should be treated as having a character of amedical  experiment.  Therefore,  it  is  necessary  to  tighten  cooperation  with  recommendedcenters using the therapy and verification of the obtained results by expanding the researchand  performing  more  extensive  research,  for  example  on  an  animal  model.  It  is  worthmentioning the extremely important question of the importance of research, from a social andethical point of view. Due to the limited access to scientific studies addressing a given topic and asmall number of data the authors' doubts that the effects of the therapy on the fertilized egg celland potential future embryonic development are caused by the influence of hyperbaric oxygentherapy. Smaller doubts concern the support of male infertility treatment regarding sperm. Inconclusion, it should be clearly stated that the results of the application of oxybarotherapy inthe treatment of couples with impaired uterine fertility are very promising. Therapy seems tobe safe and minimally invasive. Due to the unsatisfactory results of hormonal treatment, theintroduction of hyperbaric oxygen therapy as a method supporting the standardized treatmentof fertility impairment seems to be fully valid. For this purpose, research on the effectiveness ofthe  described  method  of  supporting  infertility  treatment  should  be  extended  and  subjected  tointernational discussion to those recommending the placement of oxybarotherapy and broadening theindications for its use.11 Гоженко, А.И. Очерки теории болезни. Одеса. 2010. = Gozhenko, A.I. Ocherki teorii bolezni. Odesa.2010. = Gozhenko, A.I. [Essays of the theory of disease]. Odesa. 2010.12 Запорожан, В.М., Гоженко, А.І. Від біоетики до нооетики. Вісник НАН України. 2004; 12: 22-29.=  Zaporozhan,  V.M.,  Gozhenko,  A.І.  Vіd  bіoetiki  do  nooetiki.  Vіsnik  NAN  Ukraїni.  2004;  12:  22-29.  =Zaporozhan, V.M., Gozhenko, A.І. [From bioethics to noo-ethics]. Vіsnik NAN Ukraїni. 2004; 12: 22-29.13 Билецкий,  С.В.,  Гоженко,  А.И.  Гипоксически-гиперкапнические  тренировки  в  кардиологии.Черновцы. 2007.  = Bileckij,  S.V.,  Gozhenko,  A.I.  Gipoksicheski-giperkapnicheskie trenirovki  v kardiologii.Chernovcy. 2007. = Bileckij, S.V., Gozhenko, A.I. [Hypoxic-hypercapnic exercises in cardiology]. Chernovcy.2007.266Not without significance is the fact that decisions of polish payer - National Health Fund (pol.Narodowy Fundusz Zdrowia), who is contracting hyperbaric treatment in Poland, are based on suchrecommendation. ConclusionsInitial conclusions are as follows:1.  Oxybarotherapy  has  a  beneficial  effect  on  pregnancy  implantation  by  improvingendometrial susceptibility. 2. Oxybarotherapy accelerates the growth of the endometrium, improves its blood supply andoxygenation. 3. Oxybarotherapy has a beneficial effect on sperm cell viability and motility.4. The inclusion of oxybarotherapy as a supporting method for improving fertility should beconsidered in Poland.Literature1. Bartnik E., Hołówka J., Szawarski Z., Zaremba J., Zielińska E. Założenia regulacji prawnejdotyczącej  wspomaganej  medycznie  prokreacji,  stanowisko  końcowe sformułowane  przezgrupę ekspertów biorących udział w pracach tzw.  Komisji Gowina. Warszawa, październik2008 r.2. Jovanovic A.M. Hyperbaric Oxygenation Therapy in Infertility Patients. Crit Care Obst &Gyne. 2016; 2:1. doi:10.21767/2471-9803.100012.3.  Łepecka-Klusek  C.,  Pilewska-Kozak  A.B.,  Niepłodność  w świetle  definicji  chorobypodanej przez WHO. Medycyna Ogólna i Nauki o Zdrowiu, 2012; 18(2): 162–165.4.  Sieroń A.,  Cieślar  G.  Zarys medycyny hiperbarycznej,  wyd. II  α-medica 2007 Bielsko-Biała. 23.5.  Skrzypulec  V.,  Nowosielski  K.,  Drosdzol  A.,  Kowalaczyk  R.  Sexual  dysfunctions  inselected endocrinopathies. Endokrynologia Polska. 2005; 6(56): 964-969.6. Zielińska E. Opinia sporządzona 21  maja 2015  r. na zlecenie Biura Analiz Sejmowych(druk  sejmowy  nr 3245/VII  kad.);  na  temat  rządowego  projektu  ustawy  o leczeniuniepłodności; Zeszyty Prawnicze Biura Analiz Sejmowych Kancelarii Sejmu). 2015; 4(48):183–196.7. Гоженко, А.И. Очерки теории болезни. Одеса. 2010. = Gozhenko, A.I. Ocherki teoriibolezni. Odesa. 2010. = Gozhenko, A.I. [Essays of the theory of disease]. Odesa. 2010.8. Запорожан, В.М., Гоженко, А.І. Від біоетики до нооетики. Вісник НАН України. 2004;12:  22-29.  =  Zaporozhan,  V.M.,  Gozhenko,  A.І.  Vіd  bіoetiki  do  nooetiki.  Vіsnik  NAN267Ukraїni. 2004; 12: 22-29. = Zaporozhan, V.M., Gozhenko, A.І. [From bioethics to noo-ethics].Vіsnik NAN Ukraїni. 2004; 12: 22-29.9.  Билецкий,  С.В.,  Гоженко,  А.И.  Гипоксически-гиперкапнические  тренировки  вкардиологии.  Черновцы.  2007.  =  Bileckij,  S.V.,  Gozhenko,  A.I.  Gipoksicheski-giperkapnicheskie trenirovki v kardiologii. Chernovcy. 2007. = Bileckij, S.V., Gozhenko, A.I.[Hypoxic-hypercapnic exercises in cardiology]. Chernovcy. 2007.268

Oxybarotherapy of uterine infertility

Zieliński Ewa, Dzięgielewski Piotr, Sas Katarzyna, Olszański Romuald, Zukow Walery. Oxybarotherapy of uterine infertility. Journal of Education, Health and Sport. 2018;8(12):262-268. eISNN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.2222348

http://ojs.ukw.edu.pl/index.phpohs/article/view/6372

https://pbn.nauka.gov.pl/sedno-webapp/works/891389

 

 

 

 

 

The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part b item 1223 (26/01/2017).

1223 Journal of Education, Health and Sport eissn 2391-8306 7

 

© The Authors 2018;

This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland

Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license Share alike.

(http://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited.

 

The authors declare that there is no conflict of interests regarding the publication of this paper.

 

Received: 10.11.2018. Revised: 20.11.2018. Accepted: 12.12.2018.

 

 

 

 

 

Oxybarotherapy of uterine infertility

Oxybaroterapia niepłodności maciczopochodnej


 

Ewa Zieliński1, Piotr Dzięgielewski2, Katarzyna Sas3,

Romuald Olszański4, Walery Zukow5


 

 

1Department of Emergency Medicine and Catastrophe Medicine of Collegium Medicum in Bydgoszcz, University of Mikołaj Kopernik in Toruń, Poland

 

2SPZOZ 10 Military Clinical Hospital with Policlinics in Bydgoszcz, Poland

 

3Department and Division of Pedagogics and Nurse Didactics of Collegium Medicum in Bydgoszcz, Mikołaj Kopernik University in Toruń, Poland

 

4Department of Maritime and Hyperbaric Medicine, Military Medical Institute of Gdynia, Poland

 

5Department of Spatial Management and Tourism, Faculty of Earth Sciences,

Nicolaus Copernicus University in Torun, Torun, Poland

 

 

 

 

 

Słowa kluczowe: hiperbaria, choroby, niepłodność

Key words: hyperbaria, disease, infertility


 

 

 

Abstrakt

W pracy podjęto problem Oxybaroterapii niepłodności maciczopochodnej, jako propozycji bezpiecznej uzupełniającej metody poprawy płodności. Przedstawiono możliwości zastosowania hiperbarii tlenowej i nowe kierunki jej zastosowania. Wskazania terapii hiperbarycznej są stale modyfikowane i dostrzega się nowe pola jej zastosowań. Opisano projekt wykorzystania hiperabrii tlenowej na świecie i wskazano na możliwość zaimplementowania terapii do Polski. Przedstawiono korzyści wynikające z zastosowania terapii uzupełniającej, jaką jest hiperbaria tlenowa w leczeniu par z upośledzona płodności maciczozależną.


 

Abstract

The problem of oxybarotherapy of uterine infertility was proposed as a proposition of a safe complementary method of fertility improvement. The possibilities of using hyperbaric therapy and new directions of its application have been presented. Indications of hyperbaric therapy are constantly modified and new fields of its applications are noticed. A project for the use of aerobic hyperbole in the world was described and the possibility of implementing therapy to Poland was indicated. The benefits of supplementary therapy, which is oksybaroterapy in the treatment of couples with impaired uterine fertility, are presented

Oxybarotherapy of uterine infertility

Abstract

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