Adelheid Cerwenka

Alex Braiman

Amir Aharoni

Angel Porgador

Benyamin Rosental

Dafna Oz

Fabian Afergan

Kerry S. Campbell

Lior Ann Rosenberg

Michael Brusilovsky

Michael Y. Appel

Rami Yossef

Robertson

Uzi Hadad

Abstract
               NK cells play an important role in the early immune response to cancer. The NKp44 activating receptor is the only natural cytotoxicity receptor that is expressed exclusively by primate NK cells, yet its cellular ligands remain largely unknown. Proliferating cell nuclear Ag (PCNA) is overexpressed in cancer cells. In this study, we show that the NKp44 receptor recognizes PCNA. Their interaction inhibits NK cell function through NKp44/ITIM. The physical interaction of NKp44 and PCNA is enabled by recruitment of target cell PCNA to the NK immunological synapse. We demonstrate that PCNA promotes cancer survival by immune evasion through inhibition of NKp44-mediated NK cell attack.</jats:p

Crossref

The Journal of Immunology

Proliferating Cell Nuclear Antigen Is a Novel Inhibitory Ligand for the Natural Cytotoxicity Receptor NKp44

Proliferating Cell Nuclear Antigen Is a Novel Inhibitory Ligand for the Natural Cytotoxicity Receptor NKp44

Abstract

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