Anding Zhang

Jingfa Xiao

Kaisong Huang

Meilin Jin

Qiang Zhang

Yajing Song

Zhewen Zhang

ABSTRACT
          
            Spectinomycin is an aminocyclitol antibiotic used clinically to treat a variety of infections in animals. Here, we characterized drug resistance prevalence in clinical
            Streptococcus suis
            isolates and discovered a novel resistance mechanism in which the s5 mutation (Gly26Asp) results in high spectinomycin resistance. Additionally, a novel integrative and conjugative element encompassing a multidrug resistance
            spw_like-aadE-lnu
            (B)-
            lsa
            (E) cluster and a cadmium resistance operon were identified, suggesting a possible cause for the wide dissemination of spectinomycin resistance in
            S. suis
            .
          </jats:p

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Antimicrobial Agents and Chemotherapy

Characterization of Spectinomycin Resistance in Streptococcus suis Leads to Two Novel Insights into Drug Resistance Formation and Dissemination Mechanism

Characterization of Spectinomycin Resistance in Streptococcus suis Leads to Two Novel Insights into Drug Resistance Formation and Dissemination Mechanism

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