Selected herbal drugs of family Apiaceae

Abstract

U okviru ovog diplomskog rada provedena je kvalitativna analiza biljnih droga Anisi fructus, Foeniculi fructus, Carvi fructus i Coriandri fructus te iz njih izoliranih eteričnih ulja. Kvalitativna analiza provedena je metodom tankoslojne kromatografije kojom je potvrđen identitet biljnih droga i eteričnih ulja. Metodom destilacije pomoću vodene pare određen je sadržaj eteričnih ulja u navedenim drogama pri čemu je samo droga Coriandri fructus odgovarala zahtjevu Europske farmakopeje. Dan je pregled pretkliničkih i kliničkih istraživanja odabranih biljnih droga te iz njih izoliranih eteričnih ulja te su navedene i njihove toksikološke značajke. Dobiveni podaci daju uvid u opravdanost primjene, sigurnosni profil te u nove mogućnosti primjene navedenih droga.This thesis summarizes the results of the qualitative analysis of the following herbal drugs, Anisi fructus, Foeniculi dulcis fructus, Carvi fructus and Coriandri fructus, as well as their essential oils which were isolated by hydrodistillation. The qualitative analysis of the above-mentioned herbal drugs was carried out by thin-layer chromatography, thus confirming the identity of the herbals drugs and their essential oils. According to the demands of the European Pharmacopoeia, the hydrodistillation method demonstrated insufficient essential oil content in all fruits with the exception of Coriandri fructus. An overview of the preclinical and clinical studies on selected herbal drugs and their essential oils, as well as their toxicological properties, is also given in this thesis. The collected data give insight into the justified application and safety profile of the above-mentioned herbal drugs, as well as new possibilities of their application